Stereotyped patterns of B-cell receptor in splenic marginal zone lymphoma

S. Zibellini, D. Capello, F. Forconi, Paolo Marcatili, D. Rossi, S. Rattotti, S. Franceschetti, E. Sozzi, E. Cencini, R. Marasca, Luca Baldini, Alessandra Tucci, Francesco Bertoni, Francesco Passamonti, Ester Orlandi, Marzia Varettoni, Michele Merli, Silvia Rizzi, Valter Gattei, Anna Tramontano & 3 others Marco Paulli, Gianluca Gaidano, Luca Arcaini

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Antigen stimulation may be important for splenic marginal zone lymphoma pathogenesis. To address this hypothesis, the occurrence of stereotyped B-cell receptors was investigated in 133 SMZL (26 HCV+) compared with 4,414 HCDR3 sequences from public databases. Sixteen SMZL (12%) showed stereotyped BCR; 7 of 86 (8%) SMZL sequences retrieved from public databases also belonged to stereotyped HCDR3 subsets. Three categories of subsets were identified:
i) “SMZL-specific subsets” (n=5), composed only of 12 SMZL (9 HCV- from our series); ii) “Non-Hodgkin’s lymphoma-like subsets” (n=5), comprising 5 SMZL (4 from our series) clustering with other indolent lymphomas; iii) “CLL-like subsets” (n=6), comprising 6 SMZL (3 from our series) that belonged to known CLL subsets (n=4) or clustered with public CLL sequences. Immunoglobulin 3D modeling of 3 subsets revealed similarities in antigen binding regions not limited to HCDR3. Overall, data suggest that the pathogenesis of splenic marginal zone lymphoma may involve also HCVunrelated epitopes or an antigenic trigger common to other indolent lymphomas.
Original languageEnglish
JournalHaematologica
Volume95
Issue number10
Pages (from-to)1792-1796
ISSN0390-6078
DOIs
Publication statusPublished - 2010
Externally publishedYes

Bibliographical note

This is an open-access paper.

Keywords

  • splenic marginal zone lymphoma
  • B cell receptor
  • immunoglobulin genes
  • hepatitis C virus

Cite this

Zibellini, S., Capello, D., Forconi, F., Marcatili, P., Rossi, D., Rattotti, S., ... Arcaini, L. (2010). Stereotyped patterns of B-cell receptor in splenic marginal zone lymphoma. Haematologica, 95(10), 1792-1796. https://doi.org/10.3324/haematol.2010.025437
Zibellini, S. ; Capello, D. ; Forconi, F. ; Marcatili, Paolo ; Rossi, D. ; Rattotti, S. ; Franceschetti, S. ; Sozzi, E. ; Cencini, E. ; Marasca, R. ; Baldini, Luca ; Tucci, Alessandra ; Bertoni, Francesco ; Passamonti, Francesco ; Orlandi, Ester ; Varettoni, Marzia ; Merli, Michele ; Rizzi, Silvia ; Gattei, Valter ; Tramontano, Anna ; Paulli, Marco ; Gaidano, Gianluca ; Arcaini, Luca . / Stereotyped patterns of B-cell receptor in splenic marginal zone lymphoma. In: Haematologica. 2010 ; Vol. 95, No. 10. pp. 1792-1796.
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abstract = "Antigen stimulation may be important for splenic marginal zone lymphoma pathogenesis. To address this hypothesis, the occurrence of stereotyped B-cell receptors was investigated in 133 SMZL (26 HCV+) compared with 4,414 HCDR3 sequences from public databases. Sixteen SMZL (12{\%}) showed stereotyped BCR; 7 of 86 (8{\%}) SMZL sequences retrieved from public databases also belonged to stereotyped HCDR3 subsets. Three categories of subsets were identified:i) “SMZL-specific subsets” (n=5), composed only of 12 SMZL (9 HCV- from our series); ii) “Non-Hodgkin’s lymphoma-like subsets” (n=5), comprising 5 SMZL (4 from our series) clustering with other indolent lymphomas; iii) “CLL-like subsets” (n=6), comprising 6 SMZL (3 from our series) that belonged to known CLL subsets (n=4) or clustered with public CLL sequences. Immunoglobulin 3D modeling of 3 subsets revealed similarities in antigen binding regions not limited to HCDR3. Overall, data suggest that the pathogenesis of splenic marginal zone lymphoma may involve also HCVunrelated epitopes or an antigenic trigger common to other indolent lymphomas.",
keywords = "splenic marginal zone lymphoma, B cell receptor, immunoglobulin genes, hepatitis C virus",
author = "S. Zibellini and D. Capello and F. Forconi and Paolo Marcatili and D. Rossi and S. Rattotti and S. Franceschetti and E. Sozzi and E. Cencini and R. Marasca and Luca Baldini and Alessandra Tucci and Francesco Bertoni and Francesco Passamonti and Ester Orlandi and Marzia Varettoni and Michele Merli and Silvia Rizzi and Valter Gattei and Anna Tramontano and Marco Paulli and Gianluca Gaidano and Luca Arcaini",
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Zibellini, S, Capello, D, Forconi, F, Marcatili, P, Rossi, D, Rattotti, S, Franceschetti, S, Sozzi, E, Cencini, E, Marasca, R, Baldini, L, Tucci, A, Bertoni, F, Passamonti, F, Orlandi, E, Varettoni, M, Merli, M, Rizzi, S, Gattei, V, Tramontano, A, Paulli, M, Gaidano, G & Arcaini, L 2010, 'Stereotyped patterns of B-cell receptor in splenic marginal zone lymphoma', Haematologica, vol. 95, no. 10, pp. 1792-1796. https://doi.org/10.3324/haematol.2010.025437

Stereotyped patterns of B-cell receptor in splenic marginal zone lymphoma. / Zibellini, S.; Capello, D.; Forconi, F.; Marcatili, Paolo; Rossi, D.; Rattotti, S.; Franceschetti, S.; Sozzi, E.; Cencini, E.; Marasca, R.; Baldini, Luca ; Tucci, Alessandra ; Bertoni, Francesco ; Passamonti, Francesco ; Orlandi, Ester ; Varettoni, Marzia ; Merli, Michele ; Rizzi, Silvia ; Gattei, Valter ; Tramontano, Anna ; Paulli, Marco ; Gaidano, Gianluca ; Arcaini, Luca .

In: Haematologica, Vol. 95, No. 10, 2010, p. 1792-1796.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Stereotyped patterns of B-cell receptor in splenic marginal zone lymphoma

AU - Zibellini, S.

AU - Capello, D.

AU - Forconi, F.

AU - Marcatili, Paolo

AU - Rossi, D.

AU - Rattotti, S.

AU - Franceschetti, S.

AU - Sozzi, E.

AU - Cencini, E.

AU - Marasca, R.

AU - Baldini, Luca

AU - Tucci, Alessandra

AU - Bertoni, Francesco

AU - Passamonti, Francesco

AU - Orlandi, Ester

AU - Varettoni, Marzia

AU - Merli, Michele

AU - Rizzi, Silvia

AU - Gattei, Valter

AU - Tramontano, Anna

AU - Paulli, Marco

AU - Gaidano, Gianluca

AU - Arcaini, Luca

N1 - This is an open-access paper.

PY - 2010

Y1 - 2010

N2 - Antigen stimulation may be important for splenic marginal zone lymphoma pathogenesis. To address this hypothesis, the occurrence of stereotyped B-cell receptors was investigated in 133 SMZL (26 HCV+) compared with 4,414 HCDR3 sequences from public databases. Sixteen SMZL (12%) showed stereotyped BCR; 7 of 86 (8%) SMZL sequences retrieved from public databases also belonged to stereotyped HCDR3 subsets. Three categories of subsets were identified:i) “SMZL-specific subsets” (n=5), composed only of 12 SMZL (9 HCV- from our series); ii) “Non-Hodgkin’s lymphoma-like subsets” (n=5), comprising 5 SMZL (4 from our series) clustering with other indolent lymphomas; iii) “CLL-like subsets” (n=6), comprising 6 SMZL (3 from our series) that belonged to known CLL subsets (n=4) or clustered with public CLL sequences. Immunoglobulin 3D modeling of 3 subsets revealed similarities in antigen binding regions not limited to HCDR3. Overall, data suggest that the pathogenesis of splenic marginal zone lymphoma may involve also HCVunrelated epitopes or an antigenic trigger common to other indolent lymphomas.

AB - Antigen stimulation may be important for splenic marginal zone lymphoma pathogenesis. To address this hypothesis, the occurrence of stereotyped B-cell receptors was investigated in 133 SMZL (26 HCV+) compared with 4,414 HCDR3 sequences from public databases. Sixteen SMZL (12%) showed stereotyped BCR; 7 of 86 (8%) SMZL sequences retrieved from public databases also belonged to stereotyped HCDR3 subsets. Three categories of subsets were identified:i) “SMZL-specific subsets” (n=5), composed only of 12 SMZL (9 HCV- from our series); ii) “Non-Hodgkin’s lymphoma-like subsets” (n=5), comprising 5 SMZL (4 from our series) clustering with other indolent lymphomas; iii) “CLL-like subsets” (n=6), comprising 6 SMZL (3 from our series) that belonged to known CLL subsets (n=4) or clustered with public CLL sequences. Immunoglobulin 3D modeling of 3 subsets revealed similarities in antigen binding regions not limited to HCDR3. Overall, data suggest that the pathogenesis of splenic marginal zone lymphoma may involve also HCVunrelated epitopes or an antigenic trigger common to other indolent lymphomas.

KW - splenic marginal zone lymphoma

KW - B cell receptor

KW - immunoglobulin genes

KW - hepatitis C virus

U2 - 10.3324/haematol.2010.025437

DO - 10.3324/haematol.2010.025437

M3 - Journal article

VL - 95

SP - 1792

EP - 1796

JO - Haematologica

JF - Haematologica

SN - 0390-6078

IS - 10

ER -