i) “SMZL-specific subsets” (n=5), composed only of 12 SMZL (9 HCV- from our series); ii) “Non-Hodgkin’s lymphoma-like subsets” (n=5), comprising 5 SMZL (4 from our series) clustering with other indolent lymphomas; iii) “CLL-like subsets” (n=6), comprising 6 SMZL (3 from our series) that belonged to known CLL subsets (n=4) or clustered with public CLL sequences. Immunoglobulin 3D modeling of 3 subsets revealed similarities in antigen binding regions not limited to HCDR3. Overall, data suggest that the pathogenesis of splenic marginal zone lymphoma may involve also HCVunrelated epitopes or an antigenic trigger common to other indolent lymphomas.
Bibliographical noteThis is an open-access paper.
- splenic marginal zone lymphoma
- B cell receptor
- immunoglobulin genes
- hepatitis C virus