Stereo-specific synthesis of (13r)-manoyl oxide

Björn Hamberger; Eirini Pateraki; Birger Lindberg Møller; Morten Nørholm; Morten Thrane Nielsen; Johan Andersen Ranberg; Carl Jorg Bohlman; Philip Zerbe

Stereo-specific synthesis of (13r)-manoyl oxide

Björn Hamberger (Inventor)
, Eirini Pateraki (Inventor)
, Birger Lindberg Møller (Inventor)
, Morten Nørholm (Inventor)
, Morten Thrane Nielsen (Inventor)
, Johan Andersen Ranberg (Inventor)
, Carl Jorg Bohlman (Inventor)
, Philip Zerbe (Inventor)

Novo Nordisk Foundation Center for Biosustainability

Research output: Patent

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Abstract

The present invention relates to a method for manufacturing enantiomerically pure (13R)-manoyl oxide, said method comprising the steps of contacting geranylgeranyl diphosphate (GGPP) with a class II diterpene synthase to obtain labd-13-en-8,15-diol diphosphate (LPP), and then contacting the LPP with a class I diterpene synthase to obtain (13R)-manoyl oxide. The invention further relates to (13R)-manoyl oxide obtained by the method of the invention.

Original language	English
IPC	C12N 15/ 52 A I
Patent number	WO2015091943
Filing date	25/06/2015
Country/Territory	International Bureau of the World Intellectual Property Organization (WIPO)
Priority date	20/12/2013
Priority number	EP20130198742
Publication status	Published - 25 Jun 2015

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title = "Stereo-specific synthesis of (13r)-manoyl oxide",

abstract = "The present invention relates to a method for manufacturing enantiomerically pure (13R)-manoyl oxide, said method comprising the steps of contacting geranylgeranyl diphosphate (GGPP) with a class II diterpene synthase to obtain labd-13-en-8,15-diol diphosphate (LPP), and then contacting the LPP with a class I diterpene synthase to obtain (13R)-manoyl oxide. The invention further relates to (13R)-manoyl oxide obtained by the method of the invention.",

author = "Bj{\"o}rn Hamberger and Eirini Pateraki and M{\o}ller, \{Birger Lindberg\} and Morten N{\o}rholm and Nielsen, \{Morten Thrane\} and Ranberg, \{Johan Andersen\} and Bohlman, \{Carl Jorg\} and Philip Zerbe",

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T1 - Stereo-specific synthesis of (13r)-manoyl oxide

AU - Hamberger, Björn

AU - Pateraki, Eirini

AU - Møller, Birger Lindberg

AU - Nørholm, Morten

AU - Nielsen, Morten Thrane

AU - Ranberg, Johan Andersen

AU - Bohlman, Carl Jorg

AU - Zerbe, Philip

PY - 2015/6/25

Y1 - 2015/6/25

N2 - The present invention relates to a method for manufacturing enantiomerically pure (13R)-manoyl oxide, said method comprising the steps of contacting geranylgeranyl diphosphate (GGPP) with a class II diterpene synthase to obtain labd-13-en-8,15-diol diphosphate (LPP), and then contacting the LPP with a class I diterpene synthase to obtain (13R)-manoyl oxide. The invention further relates to (13R)-manoyl oxide obtained by the method of the invention.

AB - The present invention relates to a method for manufacturing enantiomerically pure (13R)-manoyl oxide, said method comprising the steps of contacting geranylgeranyl diphosphate (GGPP) with a class II diterpene synthase to obtain labd-13-en-8,15-diol diphosphate (LPP), and then contacting the LPP with a class I diterpene synthase to obtain (13R)-manoyl oxide. The invention further relates to (13R)-manoyl oxide obtained by the method of the invention.

M3 - Patent

M1 - WO2015091943

Y2 - 2015/06/25

ER -

Stereo-specific synthesis of (13r)-manoyl oxide

Abstract

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