Stereo-specific synthesis of (13r)-manoyl oxide

Björn Hamberger (Inventor), Eirini Pateraki (Inventor), Birger Lindberg Møller (Inventor), Morten Nørholm (Inventor), Morten Thrane Nielsen (Inventor), Johan Andersen Ranberg (Inventor), Carl Jorg Bohlman (Inventor), Philip Zerbe (Inventor)

Research output: Patent

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Abstract

The present invention relates to a method for manufacturing enantiomerically pure (13R)-manoyl oxide, said method comprising the steps of contacting geranylgeranyl diphosphate (GGPP) with a class II diterpene synthase to obtain labd-13-en-8,15-diol diphosphate (LPP), and then contacting the LPP with a class I diterpene synthase to obtain (13R)-manoyl oxide. The invention further relates to (13R)-manoyl oxide obtained by the method of the invention.

Original languageEnglish
IPCC12N 15/ 52 A I
Patent numberWO2015091943
Filing date25/06/2015
CountryInternational Bureau of the World Intellectual Property Organization (WIPO)
Priority date20/12/2013
Priority numberEP20130198742
Publication statusPublished - 25 Jun 2015

Cite this

Hamberger, B., Pateraki, E., Møller, B. L., Nørholm, M., Nielsen, M. T., Ranberg, J. A., Bohlman, C. J., & Zerbe, P. (2015). IPC No. C12N 15/ 52 A I. Stereo-specific synthesis of (13r)-manoyl oxide. (Patent No. WO2015091943).