Statistical analysis of DNT detection using chemically functionalized microcantilever arrays

Filippo Bosco, M. Bache, E.-T. Hwu, C.H. Chen, S.S. Andersen, K.A. Nielsen, Stephan Sylvest Keller, Jakob Jeppesen, I.-S. Hwang, Anja Boisen

    Research output: Contribution to journalJournal articleResearchpeer-review

    Abstract

    The need for miniaturized and sensitive sensors for explosives detection is increasing in areas such as security and demining. Micrometer sized cantilevers are often used for label-free detection, and have previously been reported to be able to detect explosives. However, only a few measurements from 1 to 2 cantilevers have been reported, without any information on repeatability and reliability of the presented data. In explosive detection high reliability is needed and thus a statistical measurement approach needs to be developed and implemented. We have developed a DVD-based read-out system capable of generating large sets of cantilever data for vapor and liquid phase detection of 2,4-dinitrotoluene (DNT). Gold coated cantilevers are initially functionalized with tetraTTF-calix[4]pyrrole molecules, specifically designed to bind nitro-aromatic compounds. The selective binding of DNT molecules on the chemically treated surfaces results in significant bending of the cantilevers and in a decrease of their resonant frequencies. We present averaged measurements obtained from up to 72 cantilevers being simultaneously exposed to the same sample. Compared to integrated reference cantilevers with non-selective coatings the tetraTTF-calix[4]pyrrole functionalized cantilevers reveal a uniform and reproducible behavior.
    Original languageEnglish
    JournalSensors and Actuators B: Chemical
    Volume171-172
    Pages (from-to)1054-1059
    ISSN0925-4005
    DOIs
    Publication statusPublished - 2012

    Keywords

    • Explosives detection
    • Cantilever sensor
    • DVD-ROM
    • Optical read-out
    • Calix[4]pyrrole
    • Tetrathiafulvalene

    Cite this

    Bosco, Filippo ; Bache, M. ; Hwu, E.-T. ; Chen, C.H. ; Andersen, S.S. ; Nielsen, K.A. ; Keller, Stephan Sylvest ; Jeppesen, Jakob ; Hwang, I.-S. ; Boisen, Anja. / Statistical analysis of DNT detection using chemically functionalized microcantilever arrays. In: Sensors and Actuators B: Chemical. 2012 ; Vol. 171-172. pp. 1054-1059.
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    title = "Statistical analysis of DNT detection using chemically functionalized microcantilever arrays",
    abstract = "The need for miniaturized and sensitive sensors for explosives detection is increasing in areas such as security and demining. Micrometer sized cantilevers are often used for label-free detection, and have previously been reported to be able to detect explosives. However, only a few measurements from 1 to 2 cantilevers have been reported, without any information on repeatability and reliability of the presented data. In explosive detection high reliability is needed and thus a statistical measurement approach needs to be developed and implemented. We have developed a DVD-based read-out system capable of generating large sets of cantilever data for vapor and liquid phase detection of 2,4-dinitrotoluene (DNT). Gold coated cantilevers are initially functionalized with tetraTTF-calix[4]pyrrole molecules, specifically designed to bind nitro-aromatic compounds. The selective binding of DNT molecules on the chemically treated surfaces results in significant bending of the cantilevers and in a decrease of their resonant frequencies. We present averaged measurements obtained from up to 72 cantilevers being simultaneously exposed to the same sample. Compared to integrated reference cantilevers with non-selective coatings the tetraTTF-calix[4]pyrrole functionalized cantilevers reveal a uniform and reproducible behavior.",
    keywords = "Explosives detection, Cantilever sensor, DVD-ROM, Optical read-out, Calix[4]pyrrole, Tetrathiafulvalene",
    author = "Filippo Bosco and M. Bache and E.-T. Hwu and C.H. Chen and S.S. Andersen and K.A. Nielsen and Keller, {Stephan Sylvest} and Jakob Jeppesen and I.-S. Hwang and Anja Boisen",
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    Statistical analysis of DNT detection using chemically functionalized microcantilever arrays. / Bosco, Filippo; Bache, M.; Hwu, E.-T.; Chen, C.H.; Andersen, S.S.; Nielsen, K.A.; Keller, Stephan Sylvest; Jeppesen, Jakob; Hwang, I.-S.; Boisen, Anja.

    In: Sensors and Actuators B: Chemical, Vol. 171-172, 2012, p. 1054-1059.

    Research output: Contribution to journalJournal articleResearchpeer-review

    TY - JOUR

    T1 - Statistical analysis of DNT detection using chemically functionalized microcantilever arrays

    AU - Bosco, Filippo

    AU - Bache, M.

    AU - Hwu, E.-T.

    AU - Chen, C.H.

    AU - Andersen, S.S.

    AU - Nielsen, K.A.

    AU - Keller, Stephan Sylvest

    AU - Jeppesen, Jakob

    AU - Hwang, I.-S.

    AU - Boisen, Anja

    PY - 2012

    Y1 - 2012

    N2 - The need for miniaturized and sensitive sensors for explosives detection is increasing in areas such as security and demining. Micrometer sized cantilevers are often used for label-free detection, and have previously been reported to be able to detect explosives. However, only a few measurements from 1 to 2 cantilevers have been reported, without any information on repeatability and reliability of the presented data. In explosive detection high reliability is needed and thus a statistical measurement approach needs to be developed and implemented. We have developed a DVD-based read-out system capable of generating large sets of cantilever data for vapor and liquid phase detection of 2,4-dinitrotoluene (DNT). Gold coated cantilevers are initially functionalized with tetraTTF-calix[4]pyrrole molecules, specifically designed to bind nitro-aromatic compounds. The selective binding of DNT molecules on the chemically treated surfaces results in significant bending of the cantilevers and in a decrease of their resonant frequencies. We present averaged measurements obtained from up to 72 cantilevers being simultaneously exposed to the same sample. Compared to integrated reference cantilevers with non-selective coatings the tetraTTF-calix[4]pyrrole functionalized cantilevers reveal a uniform and reproducible behavior.

    AB - The need for miniaturized and sensitive sensors for explosives detection is increasing in areas such as security and demining. Micrometer sized cantilevers are often used for label-free detection, and have previously been reported to be able to detect explosives. However, only a few measurements from 1 to 2 cantilevers have been reported, without any information on repeatability and reliability of the presented data. In explosive detection high reliability is needed and thus a statistical measurement approach needs to be developed and implemented. We have developed a DVD-based read-out system capable of generating large sets of cantilever data for vapor and liquid phase detection of 2,4-dinitrotoluene (DNT). Gold coated cantilevers are initially functionalized with tetraTTF-calix[4]pyrrole molecules, specifically designed to bind nitro-aromatic compounds. The selective binding of DNT molecules on the chemically treated surfaces results in significant bending of the cantilevers and in a decrease of their resonant frequencies. We present averaged measurements obtained from up to 72 cantilevers being simultaneously exposed to the same sample. Compared to integrated reference cantilevers with non-selective coatings the tetraTTF-calix[4]pyrrole functionalized cantilevers reveal a uniform and reproducible behavior.

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    KW - Optical read-out

    KW - Calix[4]pyrrole

    KW - Tetrathiafulvalene

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    JO - Sensors and Actuators B: Chemical

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    SN - 0925-4005

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