Statin resistance and export

Rasmus John Normand Frandsen (Inventor), Ane Ley (Inventor), Michael Naesby (Inventor)

    Research output: Patent

    63 Downloads (Pure)

    Abstract

    The present invention relates e.g. to methods of producing statins in transgenic, non-filamentous microorganisms such as Saccharomyces cerevisiae. In addition, the present invention relates to the transgenic, non-filamentous microorganisms as such as well as various uses of transmembrane statin efflux pump(s) originating from various filamentous fungi. Moreover, the present invention relates to the transferring the compactin, lovastatin or monacolin K gene cluster originating from non-filamentous fungi into easily fermentable microorganisms, followed by expression or overexpression of the efflux pump encoding genes in said microorganisms in order to increase the microorganisms resistance to statins which in turn allows for production of elevated concentrations of natural statins compared to statin-producing methods known in the art.

    Original languageEnglish
    IPCA61K 31/ 20 A N
    Patent numberWO2015161856
    Filing date29/10/2015
    Country/TerritoryInternational Bureau of the World Intellectual Property Organization (WIPO)
    Priority date23/04/2014
    Priority numberEP20140165696
    Publication statusPublished - 29 Oct 2015

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