Statement on advancing the assessment of chemical mixtures and their risks for human health and the environment

Elina Drakvik*, Rolf Altenburger, Yasunobu Aoki, Thomas Backhaus, Tina Bahadori, Robert Barouki, Werner Brack, Mark T.D. Cronin, Barbara Demeneix, Susanne Hougaard Bennekou, Jacob van Klaveren, Carsten Kneuer, Marike Kolossa-Gehring, Erik Lebret, Leo Posthuma, Lena Reiber, Cynthia Rider, Joëlle Rüegg, Giuseppe Testa, Bart van der Burg & 6 others Hilko van der Voet, A. Michael Warhurst, Bob van de Water, Kunihiko Yamazaki, Mattias Öberg, Åke Bergman

*Corresponding author for this work

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Abstract

The number of anthropogenic chemicals, manufactured, by-products, metabolites and abiotically formed transformation products, counts to hundreds of thousands, at present. Thus, humans and wildlife are exposed to complex mixtures, never one chemical at a time and rarely with only one dominating effect. Hence there is an urgent need to develop strategies on how exposure to multiple hazardous chemicals and the combination of their effects can be assessed. A workshop, “Advancing the Assessment of Chemical Mixtures and their Risks for Human Health and the Environment” was organized in May 2018 together with Joint Research Center in Ispra, EU-funded research projects and Commission Services and relevant EU agencies. This forum for researchers and policy-makers was created to discuss and identify gaps in risk assessment and governance of chemical mixtures as well as to discuss state of the art science and future research needs. Based on the presentations and discussions at this workshop we want to bring forward the following Key Messages:
•We are at a turning point: multiple exposures and their combined effects require better management to protect public health and the environment from hazardous chemical mixtures.

•Regulatory initiatives should be launched to investigate the opportunities for all relevant regulatory frameworks to include prospective mixture risk assessment and consider combined exposures to (real-life) chemical mixtures to humans and wildlife, across sectors.

•Precautionary approaches and intermediate measures (e.g. Mixture Assessment Factor) can already be applied, although, definitive mixture risk assessments cannot be routinely conducted due to significant knowledge and data gaps.

•A European strategy needs to be set, through stakeholder engagement, for the governance of combined exposure to multiple chemicals and mixtures. The strategy would include research aimed at scientific advancement in mechanistic understanding and modelling techniques, as well as research to address regulatory and policy needs. Without such a clear strategy, specific objectives and common priorities, research, and policies to address mixtures will likely remain scattered and insufficient.
Original languageEnglish
Article number105267
JournalEnvironment International
Volume134
Number of pages7
ISSN0160-4120
DOIs
Publication statusPublished - 2020

Keywords

  • Chemical mixtures
  • Environmental chemicals
  • Combined exposure
  • Mixture risk assessment
  • Risk management

Cite this

Drakvik, E., Altenburger, R., Aoki, Y., Backhaus, T., Bahadori, T., Barouki, R., ... Bergman, Å. (2020). Statement on advancing the assessment of chemical mixtures and their risks for human health and the environment. Environment International, 134, [105267]. https://doi.org/10.1016/j.envint.2019.105267
Drakvik, Elina ; Altenburger, Rolf ; Aoki, Yasunobu ; Backhaus, Thomas ; Bahadori, Tina ; Barouki, Robert ; Brack, Werner ; Cronin, Mark T.D. ; Demeneix, Barbara ; Bennekou, Susanne Hougaard ; van Klaveren, Jacob ; Kneuer, Carsten ; Kolossa-Gehring, Marike ; Lebret, Erik ; Posthuma, Leo ; Reiber, Lena ; Rider, Cynthia ; Rüegg, Joëlle ; Testa, Giuseppe ; van der Burg, Bart ; van der Voet, Hilko ; Warhurst, A. Michael ; van de Water, Bob ; Yamazaki, Kunihiko ; Öberg, Mattias ; Bergman, Åke. / Statement on advancing the assessment of chemical mixtures and their risks for human health and the environment. In: Environment International. 2020 ; Vol. 134.
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abstract = "The number of anthropogenic chemicals, manufactured, by-products, metabolites and abiotically formed transformation products, counts to hundreds of thousands, at present. Thus, humans and wildlife are exposed to complex mixtures, never one chemical at a time and rarely with only one dominating effect. Hence there is an urgent need to develop strategies on how exposure to multiple hazardous chemicals and the combination of their effects can be assessed. A workshop, “Advancing the Assessment of Chemical Mixtures and their Risks for Human Health and the Environment” was organized in May 2018 together with Joint Research Center in Ispra, EU-funded research projects and Commission Services and relevant EU agencies. This forum for researchers and policy-makers was created to discuss and identify gaps in risk assessment and governance of chemical mixtures as well as to discuss state of the art science and future research needs. Based on the presentations and discussions at this workshop we want to bring forward the following Key Messages:•We are at a turning point: multiple exposures and their combined effects require better management to protect public health and the environment from hazardous chemical mixtures.•Regulatory initiatives should be launched to investigate the opportunities for all relevant regulatory frameworks to include prospective mixture risk assessment and consider combined exposures to (real-life) chemical mixtures to humans and wildlife, across sectors.•Precautionary approaches and intermediate measures (e.g. Mixture Assessment Factor) can already be applied, although, definitive mixture risk assessments cannot be routinely conducted due to significant knowledge and data gaps.•A European strategy needs to be set, through stakeholder engagement, for the governance of combined exposure to multiple chemicals and mixtures. The strategy would include research aimed at scientific advancement in mechanistic understanding and modelling techniques, as well as research to address regulatory and policy needs. Without such a clear strategy, specific objectives and common priorities, research, and policies to address mixtures will likely remain scattered and insufficient.",
keywords = "Chemical mixtures, Environmental chemicals, Combined exposure, Mixture risk assessment, Risk management",
author = "Elina Drakvik and Rolf Altenburger and Yasunobu Aoki and Thomas Backhaus and Tina Bahadori and Robert Barouki and Werner Brack and Cronin, {Mark T.D.} and Barbara Demeneix and Bennekou, {Susanne Hougaard} and {van Klaveren}, Jacob and Carsten Kneuer and Marike Kolossa-Gehring and Erik Lebret and Leo Posthuma and Lena Reiber and Cynthia Rider and Jo{\"e}lle R{\"u}egg and Giuseppe Testa and {van der Burg}, Bart and {van der Voet}, Hilko and Warhurst, {A. Michael} and {van de Water}, Bob and Kunihiko Yamazaki and Mattias {\"O}berg and Åke Bergman",
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Drakvik, E, Altenburger, R, Aoki, Y, Backhaus, T, Bahadori, T, Barouki, R, Brack, W, Cronin, MTD, Demeneix, B, Bennekou, SH, van Klaveren, J, Kneuer, C, Kolossa-Gehring, M, Lebret, E, Posthuma, L, Reiber, L, Rider, C, Rüegg, J, Testa, G, van der Burg, B, van der Voet, H, Warhurst, AM, van de Water, B, Yamazaki, K, Öberg, M & Bergman, Å 2020, 'Statement on advancing the assessment of chemical mixtures and their risks for human health and the environment', Environment International, vol. 134, 105267. https://doi.org/10.1016/j.envint.2019.105267

Statement on advancing the assessment of chemical mixtures and their risks for human health and the environment. / Drakvik, Elina; Altenburger, Rolf; Aoki, Yasunobu; Backhaus, Thomas; Bahadori, Tina; Barouki, Robert; Brack, Werner; Cronin, Mark T.D.; Demeneix, Barbara; Bennekou, Susanne Hougaard; van Klaveren, Jacob; Kneuer, Carsten; Kolossa-Gehring, Marike; Lebret, Erik; Posthuma, Leo; Reiber, Lena; Rider, Cynthia; Rüegg, Joëlle; Testa, Giuseppe; van der Burg, Bart; van der Voet, Hilko; Warhurst, A. Michael; van de Water, Bob; Yamazaki, Kunihiko; Öberg, Mattias; Bergman, Åke.

In: Environment International, Vol. 134, 105267, 2020.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Statement on advancing the assessment of chemical mixtures and their risks for human health and the environment

AU - Drakvik, Elina

AU - Altenburger, Rolf

AU - Aoki, Yasunobu

AU - Backhaus, Thomas

AU - Bahadori, Tina

AU - Barouki, Robert

AU - Brack, Werner

AU - Cronin, Mark T.D.

AU - Demeneix, Barbara

AU - Bennekou, Susanne Hougaard

AU - van Klaveren, Jacob

AU - Kneuer, Carsten

AU - Kolossa-Gehring, Marike

AU - Lebret, Erik

AU - Posthuma, Leo

AU - Reiber, Lena

AU - Rider, Cynthia

AU - Rüegg, Joëlle

AU - Testa, Giuseppe

AU - van der Burg, Bart

AU - van der Voet, Hilko

AU - Warhurst, A. Michael

AU - van de Water, Bob

AU - Yamazaki, Kunihiko

AU - Öberg, Mattias

AU - Bergman, Åke

PY - 2020

Y1 - 2020

N2 - The number of anthropogenic chemicals, manufactured, by-products, metabolites and abiotically formed transformation products, counts to hundreds of thousands, at present. Thus, humans and wildlife are exposed to complex mixtures, never one chemical at a time and rarely with only one dominating effect. Hence there is an urgent need to develop strategies on how exposure to multiple hazardous chemicals and the combination of their effects can be assessed. A workshop, “Advancing the Assessment of Chemical Mixtures and their Risks for Human Health and the Environment” was organized in May 2018 together with Joint Research Center in Ispra, EU-funded research projects and Commission Services and relevant EU agencies. This forum for researchers and policy-makers was created to discuss and identify gaps in risk assessment and governance of chemical mixtures as well as to discuss state of the art science and future research needs. Based on the presentations and discussions at this workshop we want to bring forward the following Key Messages:•We are at a turning point: multiple exposures and their combined effects require better management to protect public health and the environment from hazardous chemical mixtures.•Regulatory initiatives should be launched to investigate the opportunities for all relevant regulatory frameworks to include prospective mixture risk assessment and consider combined exposures to (real-life) chemical mixtures to humans and wildlife, across sectors.•Precautionary approaches and intermediate measures (e.g. Mixture Assessment Factor) can already be applied, although, definitive mixture risk assessments cannot be routinely conducted due to significant knowledge and data gaps.•A European strategy needs to be set, through stakeholder engagement, for the governance of combined exposure to multiple chemicals and mixtures. The strategy would include research aimed at scientific advancement in mechanistic understanding and modelling techniques, as well as research to address regulatory and policy needs. Without such a clear strategy, specific objectives and common priorities, research, and policies to address mixtures will likely remain scattered and insufficient.

AB - The number of anthropogenic chemicals, manufactured, by-products, metabolites and abiotically formed transformation products, counts to hundreds of thousands, at present. Thus, humans and wildlife are exposed to complex mixtures, never one chemical at a time and rarely with only one dominating effect. Hence there is an urgent need to develop strategies on how exposure to multiple hazardous chemicals and the combination of their effects can be assessed. A workshop, “Advancing the Assessment of Chemical Mixtures and their Risks for Human Health and the Environment” was organized in May 2018 together with Joint Research Center in Ispra, EU-funded research projects and Commission Services and relevant EU agencies. This forum for researchers and policy-makers was created to discuss and identify gaps in risk assessment and governance of chemical mixtures as well as to discuss state of the art science and future research needs. Based on the presentations and discussions at this workshop we want to bring forward the following Key Messages:•We are at a turning point: multiple exposures and their combined effects require better management to protect public health and the environment from hazardous chemical mixtures.•Regulatory initiatives should be launched to investigate the opportunities for all relevant regulatory frameworks to include prospective mixture risk assessment and consider combined exposures to (real-life) chemical mixtures to humans and wildlife, across sectors.•Precautionary approaches and intermediate measures (e.g. Mixture Assessment Factor) can already be applied, although, definitive mixture risk assessments cannot be routinely conducted due to significant knowledge and data gaps.•A European strategy needs to be set, through stakeholder engagement, for the governance of combined exposure to multiple chemicals and mixtures. The strategy would include research aimed at scientific advancement in mechanistic understanding and modelling techniques, as well as research to address regulatory and policy needs. Without such a clear strategy, specific objectives and common priorities, research, and policies to address mixtures will likely remain scattered and insufficient.

KW - Chemical mixtures

KW - Environmental chemicals

KW - Combined exposure

KW - Mixture risk assessment

KW - Risk management

U2 - 10.1016/j.envint.2019.105267

DO - 10.1016/j.envint.2019.105267

M3 - Journal article

VL - 134

JO - Environment International

JF - Environment International

SN - 0160-4120

M1 - 105267

ER -