TY - JOUR
T1 - Stability of diphenylalanine peptide nanotubes under liquid conditions
AU - Andersen, Karsten Brandt
AU - Castillo, Jaime
AU - Hedstrom, Martin
AU - Svendsen, Winnie Edith
PY - 2011
Y1 - 2011
N2 - Over the last couple of years, self-organizing nanotubes based on the dipeptide diphenylalanine have
received much attention, mainly as possible building blocks for the next generation of biosensors and as
drug delivery systems. One of the main reasons for this large interest is that these peptide nanotubes are
believed to be very stable both thermally and chemically. Previously, the chemical and thermal stability
of self-organizing structures has been investigated after the evaporation of the solvent. However, it was
recently discovered that the stability of the structures differed significantly when the tubes were in
solution. It has been shown that, in solution, the peptide nanotubes can easily be dissolved in several
solvents including water. It is therefore of critical importance that the stability of the nanotubes in
solution and not after solvent evaporation be investigated prior to applications in which the nanotube
will be submerged in liquid. The present article reports results demonstrating the instability and
suggests a possible approach to a stabilization procedure, which drastically improves the stability of the
formed structures. The results presented herein provide new information regarding the stability of selforganizing
diphenylalanine nanotubes in solution.
AB - Over the last couple of years, self-organizing nanotubes based on the dipeptide diphenylalanine have
received much attention, mainly as possible building blocks for the next generation of biosensors and as
drug delivery systems. One of the main reasons for this large interest is that these peptide nanotubes are
believed to be very stable both thermally and chemically. Previously, the chemical and thermal stability
of self-organizing structures has been investigated after the evaporation of the solvent. However, it was
recently discovered that the stability of the structures differed significantly when the tubes were in
solution. It has been shown that, in solution, the peptide nanotubes can easily be dissolved in several
solvents including water. It is therefore of critical importance that the stability of the nanotubes in
solution and not after solvent evaporation be investigated prior to applications in which the nanotube
will be submerged in liquid. The present article reports results demonstrating the instability and
suggests a possible approach to a stabilization procedure, which drastically improves the stability of the
formed structures. The results presented herein provide new information regarding the stability of selforganizing
diphenylalanine nanotubes in solution.
U2 - 10.1039/c0nr00734j
DO - 10.1039/c0nr00734j
M3 - Journal article
SN - 2040-3372
VL - 3
SP - 994
EP - 998
JO - Nanoscale
JF - Nanoscale
IS - 3
ER -