Spread of LA-MRSA CC398 in Danish mink (Neovison vison) and mink farm workers

Julie Elvekjær Hansen*, Marc Stegger, Karl Pedersen, Raphael N. Sieber, Jesper Larsen, Gitte Larsen, Berit Lilje, Mariann Chriél, Paal S. Andersen, Anders R. Larsen

*Corresponding author for this work

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Abstract

More than 55 million mink skins were produced globally in 2017. As a consequence, a large number of people are employed in mink production worldwide. In Denmark, farmed mink were found to constitute a reservoir of methicillin-resistant Staphylococcus aureus (MRSA) clonal complex (CC) 398 and 6000 mink farm workers in Denmark are potentially exposed to LA-MRSA CC398. The study aim was to elucidate the source of LA-MRSA CC398 in mink farms and to investigate possible transmission to humans. In total, 161 LA-MRSA CC398 isolates from mink (n = 65), mink feed (n = 16) and humans (n = 80) with reported contact to mink, were whole-genome sequenced and compared to 183 LA-MRSA CC398 isolates from Danish pigs and an international collection of 89 S. aureus CC398 isolates. Most of the mink-associated isolates clustered within the predominant LA-MRSA CC398 lineages circulating in the Danish pig production, supporting that pigs are a source of LA-MRSA CC398 in mink feed, mink, and mink farmers.
Original languageEnglish
Article number108705
JournalVeterinary Microbiology
Volume245
Number of pages5
ISSN0378-1135
DOIs
Publication statusPublished - 2020

Keywords

  • LA-MRSA CC398
  • Mink farm workers
  • Mink feed
  • Danish pig lineages
  • Spillover

Cite this

Hansen, J. E., Stegger, M., Pedersen, K., Sieber, R. N., Larsen, J., Larsen, G., Lilje, B., Chriél, M., Andersen, P. S., & Larsen, A. R. (2020). Spread of LA-MRSA CC398 in Danish mink (Neovison vison) and mink farm workers. Veterinary Microbiology, 245, [108705]. https://doi.org/10.1016/j.vetmic.2020.108705