Spin-State-Selective Excitation. Application for E.COSY-Type Measurement of JHHCoupling Constants

Axel Meissner, Jens Øllgaard Duus, Ole Winneche Sørensen

Research output: Contribution to journalJournal articleResearchpeer-review


A new pulse sequence element, spin-state-selective excitation (S3E), is introduced and combined with E.COSY-type techniques for measurement of 1H-1H J coupling constants, (S3E) edits the two resonances of a doublet prior to an evolution period of a multidimensional experiment and results in a subspectrum for each resonance, Due to this editing the large heteronuclear one-bond coupling constants normally exploited for separation of submultiplets in E.COSY-type experiments can be suppressed in experiments employing (S3E). Hence there is a concomitant effective increase in resolution, Apart from pulse imperfections and relaxation during a delay (4J)-1 S3E causes no loss of sensitivity in comparison to conventional experiments. Experimental confirmation is done using the protein RAP 17-97 (N-terminal domain of alpha(2)-macroglobulin receptor associated protein). © 1997 Academic Press.
Original languageEnglish
JournalJournal of Magnetic Resonance
Pages (from-to)92–97
Publication statusPublished - 1997
Externally publishedYes


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