Specifically targeted gene therapy for small-cell lung cancer

Camilla L. Christensen, Roza Zandi, Torben Gjetting, Frederik Cramer, Hans S. Poulsen

Research output: Contribution to journalReviewResearchpeer-review

Abstract

Small-cell lung cancer (SCLC) is a highly malignant disease with poor prognosis. Hence, there is great demand for new therapies that can replace or supplement the current available treatment regimes. Gene therapy constitutes a promising strategy and relies on the principle of introducing exogenous DNA into malignant cells causing them to die. Since SCLC is a highly disseminated malignancy, the gene therapeutic agent must be administered systemically, obligating a high level of targeting of tumor tissue and the use of delivery vehicles designed for systemic circulation of the therapeutic DNA. This review describes and discusses the current status of the application of gene therapy in relation to SCLC.
Keyword: nuclear translocation,transcriptionally targeted gene therapy,small-cell lung cancer,nonviral delivery,tumor-suppressor genes,suicide genes
Original languageEnglish
JournalExpert Review of Anticancer Therapy
Volume9
Issue number4
Pages (from-to)437-452
ISSN1473-7140
DOIs
Publication statusPublished - 2009
Externally publishedYes

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