Abstract
Small-cell lung cancer (SCLC) is a highly malignant disease with poor prognosis. Hence, there is great demand for new therapies that can replace or supplement the current available treatment regimes. Gene therapy constitutes a promising strategy and relies on the principle of introducing exogenous DNA into malignant cells causing them to die. Since SCLC is a highly disseminated malignancy, the gene therapeutic agent must be administered systemically, obligating a high level of targeting of tumor tissue and the use of delivery vehicles designed for systemic circulation of the therapeutic DNA. This review describes and discusses the current status of the application of gene therapy in relation to SCLC.
Keyword: nuclear translocation,transcriptionally targeted gene therapy,small-cell lung cancer,nonviral delivery,tumor-suppressor genes,suicide genes
Keyword: nuclear translocation,transcriptionally targeted gene therapy,small-cell lung cancer,nonviral delivery,tumor-suppressor genes,suicide genes
Original language | English |
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Journal | Expert Review of Anticancer Therapy |
Volume | 9 |
Issue number | 4 |
Pages (from-to) | 437-452 |
ISSN | 1473-7140 |
DOIs | |
Publication status | Published - 2009 |
Externally published | Yes |