Specific recognition of disaccharides in water by an artificial bicyclic carbohydrate receptor

Theis Reenberg, Nils Nyberg, Jens Øllgaard Duus, Joost L. J. van Dongen, Morten Meldal

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

We present the synthesis of a peptide-based bicyclic carbohydrate receptor capable of carbohydrate recognition in 10 % deuterated acetic acid in water. The binding constants were estimated by using NMR spectroscopy, and furthermore, a series of carbohydrate complexes were studied with the use of MS (ESI) of the complex.
Original languageEnglish
JournalEUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Issue number30
Pages (from-to)5003-5009
Number of pages7
ISSN1434-193X
DOIs
Publication statusPublished - 2007
Externally publishedYes

Keywords

  • CHEMISTRY,
  • NONCOVALENT PROTEIN COMPLEXES
  • IONIZATION MASS-SPECTROMETRY
  • GAS-PHASE BINDING
  • MOLECULAR RECOGNITION
  • NMR-SPECTROSCOPY
  • AQUEOUS-SOLUTION
  • BORONIC ACID
  • SENSITIVITY
  • PEPTIDES
  • GLUCOSE
  • combinatorial chemistry
  • molecular recognition
  • carbohydrate sensors
  • mass spectrometry
  • supramolecular chemistry
  • Carbohydrate sensors
  • Combinatorial chemistry
  • Mass spectrometry
  • Molecular recognition
  • Supramolecular chemistry

Cite this