Spatio-Temporal Neural Distance Fields for Conditional Generative Modeling of the Heart

Kristine Sørensen*, Paula Diez, Jan Margeta, Yasmin El Youssef, Michael Pham, Jonas Jalili Pedersen, Tobias Kuhl, Ole de Backer, Klaus Kofoed, Oscar Camara, Rasmus Paulsen

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingArticle in proceedingsResearchpeer-review

Abstract

The rhythmic pumping motion of the heart stands as a cornerstone in life, as it circulates blood to the entire human body through a series of carefully timed contractions of the individual chambers. Changes in the size, shape and movement of the chambers can be important markers for cardiac disease and modeling this in relation to clinical demography or disease is therefore of interest. Existing methods for spatio-temporal modeling of the human heart require shape correspondence over time or suffer from large memory requirements, making it difficult to use for complex anatomies. We introduce a novel conditional generative model, where the shape and movement is modeled implicitly in the form of a spatio-temporal neural distance field and conditioned on clinical demography. The model is based on an auto-decoder architecture and aims to disentangle the individual variations from that related to the clinical demography. It is tested on the left atrium (including the left atrial appendage), where it outperforms current state-of-the-art methods for anatomical sequence completion and generates synthetic sequences that realistically mimics the shape and motion of the real left atrium. In practice, this means we can infer functional measurements from a static image, generate synthetic populations with specified demography or disease and investigate how non-imaging clinical data effect the shape and motion of cardiac anatomies.
Original languageEnglish
Title of host publicationProceedings of the 27th International Conference on Medical Image Computing and Computer Assisted Intervention – MICCAI 2024
Volume15003
PublisherSpringer
Publication date2024
Pages422-432
ISBN (Print)978-3-031-72383-4
ISBN (Electronic)978-3-031-72384-1
DOIs
Publication statusPublished - 2024
Event27th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2024 - Marrakesh, Morocco
Duration: 6 Oct 202410 Oct 2024

Conference

Conference27th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2024
Country/TerritoryMorocco
CityMarrakesh
Period06/10/202410/10/2024
SeriesLecture Notes in Computer Science
ISSN0302-9743

Keywords

  • Neural Implicit Functions
  • Spatio-Temporal Representations
  • Multi-Modal Inputs
  • Cardiac Anatomy

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