Solid-to-solid kinetic resolution: Determination of the enantiomeric ratio

A. J J Straathof, Anders Wolff, J. J. Heijnen

Research output: Contribution to journalJournal articleResearchpeer-review


Enzymatic kinetic resolution can be carried out with a suspension of incompletely dissolved solid substrate. In favorable cases, the slowly converted enantiomer may remain as an incompletely dissolved solid and can be easily recovered. Then, such a 'solid-to-solid' resolution process will also show a significantly improved yield and productivity when compared to the reaction with completely dissolved substrate. The determination of the enantiomeric ratio (E) for reactions with suspended racemates requires equations that are different than for reactions with completely dissolved substrate. This determination becomes very complex in case of mass transfer limitation and is greatly facilitated when mass transfer limitations are absent. If the latter condition has been checked, E can be obtained from measurement of the extent of conversion and the enantiomeric excess, either of the product or of the remaining solid substrate, but not of the remaining dissolved substrate.
Original languageEnglish
JournalJournal of Molecular Catalysis B: Enzymatic
Issue number1-4
Pages (from-to)55-61
Number of pages7
Publication statusPublished - 1998
Externally publishedYes


  • Enzymatic resolution
  • Enantiomeric ratio
  • Mass transfer


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