Solid-Phase Synthesis of Small Molecule Libraries using Double                Combinatorial Chemistry

John Nielsen; Flemming R. Jensen

doi:10.1016/S0040-4039(97)00219-0

Solid-Phase Synthesis of Small Molecule Libraries using Double Combinatorial Chemistry

John Nielsen
, Flemming R. Jensen

Technical University of Denmark

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

The first synthesis of a combinatorial library using double combinatorial chemistry is presented. Coupling of unprotected Fmoc-tyrosine to the solid support was followed by Mitsunobu O-alkylation. Introduction of a diacid linker yields a system in which the double combinatorial step can be demonstrated. The resulting library of model compounds was verified by LC-MS analysis. (C) 1997 Elsevier Science Ltd.

Original language	English
Journal	Tetrahedron Letters
Volume	38
Issue number	11
Pages (from-to)	2011-2014
ISSN	0040-4039
DOIs	https://doi.org/10.1016/S0040-4039(97)00219-0
Publication status	Published - 1997

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title = "Solid-Phase Synthesis of Small Molecule Libraries using Double Combinatorial Chemistry",

abstract = "The first synthesis of a combinatorial library using double combinatorial chemistry is presented. Coupling of unprotected Fmoc-tyrosine to the solid support was followed by Mitsunobu O-alkylation. Introduction of a diacid linker yields a system in which the double combinatorial step can be demonstrated. The resulting library of model compounds was verified by LC-MS analysis. (C) 1997 Elsevier Science Ltd. ",

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year = "1997",

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AU - Nielsen, John

AU - Jensen, Flemming R.

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N2 - The first synthesis of a combinatorial library using double combinatorial chemistry is presented. Coupling of unprotected Fmoc-tyrosine to the solid support was followed by Mitsunobu O-alkylation. Introduction of a diacid linker yields a system in which the double combinatorial step can be demonstrated. The resulting library of model compounds was verified by LC-MS analysis. (C) 1997 Elsevier Science Ltd.

AB - The first synthesis of a combinatorial library using double combinatorial chemistry is presented. Coupling of unprotected Fmoc-tyrosine to the solid support was followed by Mitsunobu O-alkylation. Introduction of a diacid linker yields a system in which the double combinatorial step can be demonstrated. The resulting library of model compounds was verified by LC-MS analysis. (C) 1997 Elsevier Science Ltd.

U2 - 10.1016/S0040-4039(97)00219-0

DO - 10.1016/S0040-4039(97)00219-0

M3 - Journal article

SN - 0040-4039

VL - 38

SP - 2011

EP - 2014

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 11

ER -

Solid-Phase Synthesis of Small Molecule Libraries using Double Combinatorial Chemistry

Abstract

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