The first synthesis of a combinatorial library using double combinatorial chemistry is presented. Coupling of unprotected Fmoc-tyrosine to the solid support was followed by Mitsunobu O-alkylation. Introduction of a diacid linker yields a system in which the double combinatorial step can be demonstrated. The resulting library of model compounds was verified by LC-MS analysis. (C) 1997 Elsevier Science Ltd.
Nielsen, J., & Jensen, F. R. (1997). Solid-Phase Synthesis of Small Molecule Libraries using Double Combinatorial Chemistry. Tetrahedron Letters, 38(11), 2011-2014. https://doi.org/10.1016/S0040-4039(97)00219-0