Solid-Phase Synthesis of Small Molecule Libraries using Double Combinatorial Chemistry

John Nielsen, Flemming R. Jensen

    Research output: Contribution to journalJournal articleResearchpeer-review

    Abstract

    The first synthesis of a combinatorial library using double combinatorial chemistry is presented. Coupling of unprotected Fmoc-tyrosine to the solid support was followed by Mitsunobu O-alkylation. Introduction of a diacid linker yields a system in which the double combinatorial step can be demonstrated. The resulting library of model compounds was verified by LC-MS analysis. (C) 1997 Elsevier Science Ltd.
    Original languageEnglish
    JournalTetrahedron Letters
    Volume38
    Issue number11
    Pages (from-to)2011-2014
    ISSN0040-4039
    DOIs
    Publication statusPublished - 1997

    Cite this