Solid-Phase Synthesis of Small Molecule Libraries using Double Combinatorial Chemistry

John Nielsen, Flemming R. Jensen

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    The first synthesis of a combinatorial library using double combinatorial chemistry is presented. Coupling of unprotected Fmoc-tyrosine to the solid support was followed by Mitsunobu O-alkylation. Introduction of a diacid linker yields a system in which the double combinatorial step can be demonstrated. The resulting library of model compounds was verified by LC-MS analysis. (C) 1997 Elsevier Science Ltd.
    Original languageEnglish
    JournalTetrahedron Letters
    Issue number11
    Pages (from-to)2011-2014
    Publication statusPublished - 1997

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