Solid-Phase Synthesis of PEGylated Lipopeptides Using Click Chemistry

Rasmus Irming Jølck, Rolf Henrik Berg, Thomas Lars Andresen

    Research output: Contribution to journalJournal articleResearchpeer-review

    Abstract

    A versatile methodology for efficient synthesis of PEGylated lipopeptides via CuAAC “Click” conjugation between alkyne-bearing solid-supported lipopeptides and azido-functionalized PEGs is described. This new and very robust method offers a unique platform for synthesizing PEGylated lipopeptides with a high level of complexity. These molecules, obtained in a single purification step, are ideally suited for functionalization of solid-supported lipid bilayers and liposomal drug delivery systems and are particularly valuable in enzyme activation strategies.
    Original languageEnglish
    JournalBioconjugate Chemistry
    Volume21
    Issue number5
    Pages (from-to)807-810
    ISSN1043-1802
    DOIs
    Publication statusPublished - 2010

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