Abstract
Readily available 4,4′-bismethoxybenzhydryl azide was found to be a useful building block for the synthesis of NH-1,2,3-triazoles through copper(I)-catalyzed cycloaddition reactions with solid-supported terminal alkynes, followed by acid-mediated deprotection. Peptide-containing NH-1,2,3-triazoles were obtained in good yield and excellent purity (typically >95%)
| Original language | English |
|---|---|
| Journal | Synlett |
| Volume | 25 |
| Issue number | 13 |
| Pages (from-to) | 1891-1895 |
| ISSN | 0936-5214 |
| DOIs | |
| Publication status | Published - 2014 |
Keywords
- Organic Chemistry
- azide
- click chemistry
- cross-coupling
- N H-1,2,3-triazoles
- solid-phase synthesis
- 1,2,3 triazole derivative
- 4,4' bismethoxybenzhydryl azide
- alkyne derivative
- unclassified drug
- article
- chemical structure
- cycloaddition
- deprotection reaction
- reaction analysis
- solid phase synthesis
- stoichiometry