Solid-phase synthesis of NH-1,2,3-triazoles using 4,4′- bismethoxybenzhydryl azide

Anders Emil O'Hanlon Cohrt, Sebastian Thordal Le Quement, Thomas Eiland Nielsen

Research output: Contribution to journalLetterResearchpeer-review

Abstract

Readily available 4,4′-bismethoxybenzhydryl azide was found to be a useful building block for the synthesis of NH-1,2,3-triazoles through copper(I)-catalyzed cycloaddition reactions with solid-supported terminal alkynes, followed by acid-mediated deprotection. Peptide-containing NH-1,2,3-triazoles were obtained in good yield and excellent purity (typically >95%)
Original languageEnglish
JournalSYNLETT
Volume25
Issue number13
Pages (from-to)1891-1895
ISSN0936-5214
DOIs
Publication statusPublished - 2014

Keywords

  • Organic Chemistry
  • azide
  • click chemistry
  • cross-coupling
  • N H-1,2,3-triazoles
  • solid-phase synthesis
  • 1,2,3 triazole derivative
  • 4,4' bismethoxybenzhydryl azide
  • alkyne derivative
  • unclassified drug
  • article
  • chemical structure
  • cycloaddition
  • deprotection reaction
  • reaction analysis
  • solid phase synthesis
  • stoichiometry

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