Solid-phase synthesis of 3-amino-2-pyrazolines

John Nielsen

    Research output: Contribution to journalJournal articleResearchpeer-review


    The development of a solid-phase synthesis of 3-amino-2-pyrazolines is described. Conjugate addition of hydrazines to alpha,beta-unsaturated nitriles followed by cyclization yields 3-amino-2-pyrazolines. Acylation or sulfonation of the free amino-group yields a 24 member library of 3-amino-2-pyrazolines. (C) 1998 Elsevier Science Ltd. AII rights reserved.
    Original languageEnglish
    JournalTetrahedron Letters
    Issue number32
    Pages (from-to)5845-5848
    Publication statusPublished - 1998


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