Solid-Phase Random Glycosylation

K. Agoston, Lars Kröger, Gyula Dekany, J. Thiem

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Two different approaches were employed to study solid phase random glycosylations to obtain oligosaccharide libraries. In approach I, Wang resin esters were attached to the acceptors structures. Following their glycosylation and resin cleavage, the peracetylated components of the oligosaccharide libraries were characterized. In approach II, polymer-linked donor components could be employed and processed correspondingly. Approach I proved to be superior regarding yield and versatility of products and also allowed the formation of higher oligomers.
Original languageEnglish
JournalJournal of Combinatorial Chemistry
Volume11
Issue number5
Pages (from-to)813-819
ISSN1520-4766
DOIs
Publication statusPublished - 2009

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