Vanadium pentoxide has been proposed as a good alternative hole transport layer for improving device lifetime of organic photovoltaics. The article presents a study on the optimization of slot-die-coated vanadium oxide films produced with a roll coating machine with the aim of achieving scalable organic solar cells and photo-detectors with improved performance. The effect of different diluents on the electrical properties of the vanadium oxide films is investigated, and methodologies for efficient interfacing of the anode are studied. Furthermore, the lifetime of the cells with incorporated vanadium oxide is investigated employing different encapsulation methods. Finally, an application of the manufactured scalable devices in proximity sensors is demonstrated using a 3D-printed scaffold.