Site-selective modification of proteins

Sanne Schoffelen (Inventor), Knud Jørgen Jensen (Inventor), Kasper Kildegaard Sørensen (Inventor), Mikkel B Thygesen (Inventor), Christian Kofoed (Inventor)

Research output: Patent

48 Downloads (Pure)

Abstract

The present invention concerns a method for site-selective modification of a target protein or peptide by use of an acylation tag comprising a single lysine residue and at least three histidine residues. Upon contact with an acylating reagent, the target protein or peptide becomes modified at the ε-amine of the lysine residue of the acylation tag.

Original languageEnglish
IPCG01N 33/ 58 A I
Patent numberWO2022090520
Filing date30/10/2020
Country/TerritoryInternational Bureau of the World Intellectual Property Organization (WIPO)
Priority date30/10/2020
Priority numberEP20200204915
Publication statusPublished - 5 May 2022

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