Site-selective modification of proteins

Sanne Schoffelen; Knud Jørgen Jensen; Kasper Kildegaard Sørensen; Mikkel B Thygesen; Christian Kofoed

Site-selective modification of proteins

Sanne Schoffelen (Inventor), Knud Jørgen Jensen (Inventor), Kasper Kildegaard Sørensen (Inventor), Mikkel B Thygesen (Inventor), Christian Kofoed (Inventor)

Research output: Patent

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Abstract

The present invention concerns a method for site-selective modification of a target protein or peptide by use of an acylation tag comprising a single lysine residue and at least three histidine residues. Upon contact with an acylating reagent, the target protein or peptide becomes modified at the ε-amine of the lysine residue of the acylation tag.

Original language	English
IPC	G01N 33/ 58 A I
Patent number	WO2022090520
Filing date	30/10/2020
Country/Territory	International Bureau of the World Intellectual Property Organization (WIPO)
Priority date	30/10/2020
Priority number	EP20200204915
Publication status	Published - 5 May 2022

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title = "Site-selective modification of proteins",

abstract = "The present invention concerns a method for site-selective modification of a target protein or peptide by use of an acylation tag comprising a single lysine residue and at least three histidine residues. Upon contact with an acylating reagent, the target protein or peptide becomes modified at the ε-amine of the lysine residue of the acylation tag.",

author = "Sanne Schoffelen and Jensen, {Knud J{\o}rgen} and S{\o}rensen, {Kasper Kildegaard} and Thygesen, {Mikkel B} and Christian Kofoed",

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T1 - Site-selective modification of proteins

AU - Schoffelen, Sanne

AU - Jensen, Knud Jørgen

AU - Sørensen, Kasper Kildegaard

AU - Thygesen, Mikkel B

AU - Kofoed, Christian

PY - 2022/5/5

Y1 - 2022/5/5

N2 - The present invention concerns a method for site-selective modification of a target protein or peptide by use of an acylation tag comprising a single lysine residue and at least three histidine residues. Upon contact with an acylating reagent, the target protein or peptide becomes modified at the ε-amine of the lysine residue of the acylation tag.

AB - The present invention concerns a method for site-selective modification of a target protein or peptide by use of an acylation tag comprising a single lysine residue and at least three histidine residues. Upon contact with an acylating reagent, the target protein or peptide becomes modified at the ε-amine of the lysine residue of the acylation tag.

M3 - Patent

M1 - WO2022090520

Y2 - 2020/10/30

ER -

Site-selective modification of proteins

Abstract

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