Single walled carbon nanotube-based electrical biosensor for the label-free detection of pathogenic bacteria

S. M. Yoo, Y. K. Baek, S. Shin, J.H Kim, H. T. Jung, Y. K. Choi, Sang Yup Lee

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

We herein describe the development of a single-walled carbon nanotube (SWNT)-based electrical biosensor consisting of a two-terminal resistor, and report its use for the specific, label-free detection of pathogenic bacteria via changes in conductance. The ability of this biosensor to recognize different pathogenic bacteria was analyzed, and conditions were optimized with different probe concentrations. Using this system, the reference strains and clinical isolates of Staphylococcus aureus and Escherichia coli were successfully detected; in both cases, the sensor showed a detection limit of 10 CFU. This SWNT-based electrical biosensor will prove useful for the development of highly sensitive and specific handheld pathogen detectors.
Original languageEnglish
JournalJournal of Nanoscience and Nanotechnology
Volume16
Issue number6
Pages (from-to)6520-6525
Number of pages6
ISSN1533-4880
DOIs
Publication statusPublished - 2016

Keywords

  • Bacteria
  • Biosensor
  • DNA
  • Electrical Detection
  • Single-Walled Carbon Nanotube

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