Single-Shot-RARE for rapid 3D hyperpolarized metabolic ex vivo tissue imaging: RF-pulse design for semi-dense spectra

Research output: Contribution to conferencePosterResearchpeer-review

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Abstract

MRS of hyperpolarized (HP) 13C-enriched compounds is a promising method for in vivo cancer diagnosis . Sentinel lymph node ex vivo tissue sample histology
used in clinical routine for breast cancer metastasis diagnosis requires time consuming sample analysis. 3D-HP-MRSI can potentially speed up the diagnosis given
a sensitive marker that can be efficiently imaged in tissue after homogenous injection. The entire sample can be confined within the imaged volume giving the
possibility of complete spatial non-selectivity of the radio frequency (RF) pulses in the RF pulse design with no chemical shift localization errors. Since only a few
product signals are of interest for this application, a combination of under-sampled temporal encoding, frequency selective excitation and the Single-Shot-RAREsequence
offers favourable SNR characteristics. Small peak separations are challenging, however, since they require narrow excitation transition-bands. We have designed a 3D-MRSI pulse sequence for hyperpolarized ex vivo sample imaging for semi-dense compound spectra (few components, relatively small separations), ultimately aimed to be used for metastasis detection in excised lymph nodes.
Original languageEnglish
Publication date2016
Publication statusPublished - 2016
Event33rd ESMRMB Annual Scientific Meeting - Vienna, Austria
Duration: 29 Sep 20161 Oct 2016

Conference

Conference33rd ESMRMB Annual Scientific Meeting
CountryAustria
CityVienna
Period29/09/201601/10/2016

Bibliographical note

Proceedings of the ESMRMB 33th Annual Meeting, 322, 2016. http://epostersonline.com/esmrmb2016/node/1347

Cite this

@conference{7a073086b22d40b89b4cd1c2b092dfdd,
title = "Single-Shot-RARE for rapid 3D hyperpolarized metabolic ex vivo tissue imaging: RF-pulse design for semi-dense spectra",
abstract = "MRS of hyperpolarized (HP) 13C-enriched compounds is a promising method for in vivo cancer diagnosis . Sentinel lymph node ex vivo tissue sample histologyused in clinical routine for breast cancer metastasis diagnosis requires time consuming sample analysis. 3D-HP-MRSI can potentially speed up the diagnosis givena sensitive marker that can be efficiently imaged in tissue after homogenous injection. The entire sample can be confined within the imaged volume giving thepossibility of complete spatial non-selectivity of the radio frequency (RF) pulses in the RF pulse design with no chemical shift localization errors. Since only a fewproduct signals are of interest for this application, a combination of under-sampled temporal encoding, frequency selective excitation and the Single-Shot-RAREsequenceoffers favourable SNR characteristics. Small peak separations are challenging, however, since they require narrow excitation transition-bands. We have designed a 3D-MRSI pulse sequence for hyperpolarized ex vivo sample imaging for semi-dense compound spectra (few components, relatively small separations), ultimately aimed to be used for metastasis detection in excised lymph nodes.",
author = "P.O. Magnusson and Jensen, {Pernille Rose} and Dyrby, {Tim Bj{\o}rn} and Magnus Karlsson and Lerche, {Mathilde Hauge} and Hanson, {Lars G.}",
note = "Proceedings of the ESMRMB 33th Annual Meeting, 322, 2016. http://epostersonline.com/esmrmb2016/node/1347; 33rd ESMRMB Annual Scientific Meeting ; Conference date: 29-09-2016 Through 01-10-2016",
year = "2016",
language = "English",

}

Single-Shot-RARE for rapid 3D hyperpolarized metabolic ex vivo tissue imaging: RF-pulse design for semi-dense spectra. / Magnusson, P.O.; Jensen, Pernille Rose; Dyrby, Tim Bjørn; Karlsson, Magnus; Lerche, Mathilde Hauge; Hanson, Lars G. .

2016. Poster session presented at 33rd ESMRMB Annual Scientific Meeting, Vienna, Austria.

Research output: Contribution to conferencePosterResearchpeer-review

TY - CONF

T1 - Single-Shot-RARE for rapid 3D hyperpolarized metabolic ex vivo tissue imaging: RF-pulse design for semi-dense spectra

AU - Magnusson, P.O.

AU - Jensen, Pernille Rose

AU - Dyrby, Tim Bjørn

AU - Karlsson, Magnus

AU - Lerche, Mathilde Hauge

AU - Hanson, Lars G.

N1 - Proceedings of the ESMRMB 33th Annual Meeting, 322, 2016. http://epostersonline.com/esmrmb2016/node/1347

PY - 2016

Y1 - 2016

N2 - MRS of hyperpolarized (HP) 13C-enriched compounds is a promising method for in vivo cancer diagnosis . Sentinel lymph node ex vivo tissue sample histologyused in clinical routine for breast cancer metastasis diagnosis requires time consuming sample analysis. 3D-HP-MRSI can potentially speed up the diagnosis givena sensitive marker that can be efficiently imaged in tissue after homogenous injection. The entire sample can be confined within the imaged volume giving thepossibility of complete spatial non-selectivity of the radio frequency (RF) pulses in the RF pulse design with no chemical shift localization errors. Since only a fewproduct signals are of interest for this application, a combination of under-sampled temporal encoding, frequency selective excitation and the Single-Shot-RAREsequenceoffers favourable SNR characteristics. Small peak separations are challenging, however, since they require narrow excitation transition-bands. We have designed a 3D-MRSI pulse sequence for hyperpolarized ex vivo sample imaging for semi-dense compound spectra (few components, relatively small separations), ultimately aimed to be used for metastasis detection in excised lymph nodes.

AB - MRS of hyperpolarized (HP) 13C-enriched compounds is a promising method for in vivo cancer diagnosis . Sentinel lymph node ex vivo tissue sample histologyused in clinical routine for breast cancer metastasis diagnosis requires time consuming sample analysis. 3D-HP-MRSI can potentially speed up the diagnosis givena sensitive marker that can be efficiently imaged in tissue after homogenous injection. The entire sample can be confined within the imaged volume giving thepossibility of complete spatial non-selectivity of the radio frequency (RF) pulses in the RF pulse design with no chemical shift localization errors. Since only a fewproduct signals are of interest for this application, a combination of under-sampled temporal encoding, frequency selective excitation and the Single-Shot-RAREsequenceoffers favourable SNR characteristics. Small peak separations are challenging, however, since they require narrow excitation transition-bands. We have designed a 3D-MRSI pulse sequence for hyperpolarized ex vivo sample imaging for semi-dense compound spectra (few components, relatively small separations), ultimately aimed to be used for metastasis detection in excised lymph nodes.

M3 - Poster

ER -