Abstract
We present a magnetoresistive sensor platform for hybridization assays and demonstrate its applicability on single nucleotide polymorphism (SNP) genotyping. The sensor relies on anisotropic magnetoresistance in a new geometry with a local negative reference and uses the magnetic field from the sensor bias current to magnetize magnetic beads in the vicinity of the sensor. The method allows for real-time measurements of the specific bead binding to the sensor surface during DNA hybridization and washing. Compared to other magnetic biosensing platforms, our approach eliminates the
need for external electromagnets and thus allows for miniaturization of the sensor platform.
need for external electromagnets and thus allows for miniaturization of the sensor platform.
| Original language | English |
|---|---|
| Title of host publication | Proceedings of the 17th International Conference on Miniaturized Systems for Chemistry and Life Sciences |
| Publisher | Chemical and Biological Microsystems Society |
| Publication date | 2013 |
| Pages | 1523-1525 |
| ISBN (Electronic) | 978-0-9798064-6-9 |
| Publication status | Published - 2013 |
| Event | 17th International Conference on Miniaturized Systems for Chemistry and Life Sciences - Freiberg, Germany Duration: 27 Oct 2013 → 31 Oct 2013 Conference number: 17 http://www.microtas2013.org/ |
Conference
| Conference | 17th International Conference on Miniaturized Systems for Chemistry and Life Sciences |
|---|---|
| Number | 17 |
| Country | Germany |
| City | Freiberg |
| Period | 27/10/2013 → 31/10/2013 |
| Internet address |
Keywords
- Biosensor
- SNP genotyping
- Magnetoresistance
- Lab-on-a-chip
- DNA sensor