Single nucleotide polymorphism (SNP) detection on a magnetoresistive sensor

Giovanni Rizzi, Frederik Westergaard Østerberg, Martin Dufva, Mikkel Fougt Hansen

Research output: Chapter in Book/Report/Conference proceedingArticle in proceedingsResearchpeer-review

Abstract

We present a magnetoresistive sensor platform for hybridization assays and demonstrate its applicability on single nucleotide polymorphism (SNP) genotyping. The sensor relies on anisotropic magnetoresistance in a new geometry with a local negative reference and uses the magnetic field from the sensor bias current to magnetize magnetic beads in the vicinity of the sensor. The method allows for real-time measurements of the specific bead binding to the sensor surface during DNA hybridization and washing. Compared to other magnetic biosensing platforms, our approach eliminates the
need for external electromagnets and thus allows for miniaturization of the sensor platform.
Original languageEnglish
Title of host publicationProceedings of the 17th International Conference on Miniaturized Systems for Chemistry and Life Sciences
PublisherChemical and Biological Microsystems Society
Publication date2013
Pages1523-1525
ISBN (Electronic)978-0-9798064-6-9
Publication statusPublished - 2013
Event17th International Conference on Miniaturized Systems for Chemistry and Life Sciences - Freiberg, Germany
Duration: 27 Oct 201331 Oct 2013
Conference number: 17
http://www.microtas2013.org/

Conference

Conference17th International Conference on Miniaturized Systems for Chemistry and Life Sciences
Number17
CountryGermany
CityFreiberg
Period27/10/201331/10/2013
Internet address

Keywords

  • Biosensor
  • SNP genotyping
  • Magnetoresistance
  • Lab-on-a-chip
  • DNA sensor

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