Single-Molecule Encapsulation: A Straightforward Route to Highly Stable and Printable Enzymes

Ana Beloqui, Sarah Baur, Vanessa Trouillet, Alexander Welle, Peter Jeppe Madsen, Martin Bastmeyer, Guillaume Delaittre

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

A mild, fast, and sequence-independent method for controlled enzyme immobilization is presented. This novel approach involves the encapsulation of single-enzyme molecules and the covalent attachment of these nanobiocatalysts onto surfaces. Fast and mild immobilization conditions, combined with low nonspecific adsorption on hydrophobic substrates, enables well-defined surface patterns via microcontact printing. The biohybrid materials show enhanced activity in organic solvents.
Original languageEnglish
JournalSmall
Volume12
Issue number13
Pages (from-to)1716-1722
ISSN1613-6810
DOIs
Publication statusPublished - 2016
Externally publishedYes

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