Single-cell analysis reveals immune dysfunction from the earliest stages of CLL that can be reversed by ibrutinib

Noelia Purroy; Yuzhou Evelyn Tong; Camilla K. Lemvigh; Nicoletta Cieri; Shuqiang Li; Erin M. Parry; Wandi Zhang; Laura Z. Rassenti; Thomas J. Kipps; Susan L. Slager; Neil E. Kay; Connie Lesnick; Tait D. Shanafelt; Paolo Ghia; Lydia Scarfò; Kenneth J. Livak; Peter V. Kharchenko; Donna S. Neuberg; Lars Rønn Olsen; Jean Fan; Satyen H. Gohil; Catherine J. Wu

doi:10.1182/blood.2021013926

Single-cell analysis reveals immune dysfunction from the earliest stages of CLL that can be reversed by ibrutinib

Noelia Purroy
, Yuzhou Evelyn Tong
, Camilla K. Lemvigh
, Nicoletta Cieri
, Shuqiang Li
, Erin M. Parry
, Wandi Zhang
, Laura Z. Rassenti
, Thomas J. Kipps
, Susan L. Slager
, Neil E. Kay
, Connie Lesnick
, Tait D. Shanafelt
, Paolo Ghia
, Lydia Scarfò
, Kenneth J. Livak
, Peter V. Kharchenko
, Donna S. Neuberg
, Lars Rønn Olsen
, Jean Fan

Satyen H. Gohil, Catherine J. Wu^*

^*Corresponding author for this work

Broad Institute of Harvard University and Massachusetts Institute of Technology
Harvard University
Dana-Farber Cancer Institute
University of California at San Diego
Mayo Clinic Rochester, MN
Stanford University
Vita-Salute San Raffaele University
Johns Hopkins University
University College London

Research output: Contribution to journal › Letter › peer-review

Original language	English
Journal	Blood
Volume	139
Issue number	14
Pages (from-to)	2252-2256
ISSN	0006-4971
DOIs	https://doi.org/10.1182/blood.2021013926
Publication status	Published - 2022

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Purroy, N., Tong, Y. E., Lemvigh, C. K., Cieri, N., Li, S., Parry, E. M., Zhang, W., Rassenti, L. Z., Kipps, T. J., Slager, S. L., Kay, N. E., Lesnick, C., Shanafelt, T. D., Ghia, P., Scarfò, L., Livak, K. J., Kharchenko, P. V., Neuberg, D. S., Olsen, L. R., ... Wu, C. J. (2022). Single-cell analysis reveals immune dysfunction from the earliest stages of CLL that can be reversed by ibrutinib. Blood, 139(14), 2252-2256. https://doi.org/10.1182/blood.2021013926

@article{bea7ee75e9cc417c8bebc4fe59319646,

title = "Single-cell analysis reveals immune dysfunction from the earliest stages of CLL that can be reversed by ibrutinib",

author = "Noelia Purroy and Tong, \{Yuzhou Evelyn\} and Lemvigh, \{Camilla K.\} and Nicoletta Cieri and Shuqiang Li and Parry, \{Erin M.\} and Wandi Zhang and Rassenti, \{Laura Z.\} and Kipps, \{Thomas J.\} and Slager, \{Susan L.\} and Kay, \{Neil E.\} and Connie Lesnick and Shanafelt, \{Tait D.\} and Paolo Ghia and Lydia Scarf{\`o} and Livak, \{Kenneth J.\} and Kharchenko, \{Peter V.\} and Neuberg, \{Donna S.\} and Olsen, \{Lars R{\o}nn\} and Jean Fan and Gohil, \{Satyen H.\} and Wu, \{Catherine J.\}",

year = "2022",

doi = "10.1182/blood.2021013926",

language = "English",

volume = "139",

pages = "2252--2256",

journal = "Blood",

issn = "0006-4971",

publisher = "Elsevier",

number = "14",

}

Purroy, N, Tong, YE, Lemvigh, CK, Cieri, N, Li, S, Parry, EM, Zhang, W, Rassenti, LZ, Kipps, TJ, Slager, SL, Kay, NE, Lesnick, C, Shanafelt, TD, Ghia, P, Scarfò, L, Livak, KJ, Kharchenko, PV, Neuberg, DS, Olsen, LR, Fan, J, Gohil, SH & Wu, CJ 2022, 'Single-cell analysis reveals immune dysfunction from the earliest stages of CLL that can be reversed by ibrutinib', Blood, vol. 139, no. 14, pp. 2252-2256. https://doi.org/10.1182/blood.2021013926

TY - JOUR

T1 - Single-cell analysis reveals immune dysfunction from the earliest stages of CLL that can be reversed by ibrutinib

AU - Purroy, Noelia

AU - Tong, Yuzhou Evelyn

AU - Lemvigh, Camilla K.

AU - Cieri, Nicoletta

AU - Li, Shuqiang

AU - Parry, Erin M.

AU - Zhang, Wandi

AU - Rassenti, Laura Z.

AU - Kipps, Thomas J.

AU - Slager, Susan L.

AU - Kay, Neil E.

AU - Lesnick, Connie

AU - Shanafelt, Tait D.

AU - Ghia, Paolo

AU - Scarfò, Lydia

AU - Livak, Kenneth J.

AU - Kharchenko, Peter V.

AU - Neuberg, Donna S.

AU - Olsen, Lars Rønn

AU - Fan, Jean

AU - Gohil, Satyen H.

AU - Wu, Catherine J.

PY - 2022

Y1 - 2022

U2 - 10.1182/blood.2021013926

DO - 10.1182/blood.2021013926

M3 - Letter

C2 - 35020831

AN - SCOPUS:85127488881

SN - 0006-4971

VL - 139

SP - 2252

EP - 2256

JO - Blood

JF - Blood

IS - 14

ER -