Simultaneous PET/MRI with 13C magnetic resonance spectroscopic imaging (hyperPET): phantom-based evaluation of PET quantification

Adam E. Hansen; Flemming L. Andersen; Sarah T. Henriksen; Alexandre Vignaud; Jan Henrik Ardenkjær-Larsen; Liselotte Højgaard; Andreas  Kjær; Thomas L. Klausen

doi:10.1186/s40658-016-0143-6

Simultaneous PET/MRI with 13C magnetic resonance spectroscopic imaging (hyperPET): phantom-based evaluation of PET quantification

Adam E. Hansen
, Flemming L. Andersen
, Sarah T. Henriksen
, Alexandre Vignaud
, Jan Henrik Ardenkjær-Larsen
, Liselotte Højgaard
, Andreas Kjær
, Thomas L. Klausen

University of Copenhagen
French Alternative Energies and Atomic Energy Commission

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Abstract

Background: Integrated PET/MRI with hyperpolarized 13C magnetic resonance spectroscopic imaging (13C-MRSI) offers simultaneous, dual-modality metabolic imaging. A prerequisite for the use of simultaneous imaging is the absence of interference between the two modalities. This has been documented for a clinical whole-body system using simultaneous 1 H-MRI and PET but never for 13C-MRSI and PET. Here, the feasibility of simultaneous PET and 13C-MRSI as well as hyperpolarized 13C-MRSI in an integrated whole-body PET/MRI hybrid scanner is evaluated using phantom experiments. Methods: Combined PET and 13C-MRSI phantoms including a NEMA [18F]-FDG phantom, 13C-acetate and 13C-urea sources, and hyperpolarized 13C-pyruvate were imaged repeatedly with PET and/or 13C-MRSI. Measurements evaluated for interference effects included PET activity values in the largest sphere and a background region; total number of PET trues; and 13C-MRSI signal-to-noise ratio (SNR) for urea and acetate phantoms. Differences between measurement conditions were evaluated using t tests. Results: PET and 13C-MRSI data acquisition could be performed simultaneously without any discernible artifacts. The average difference in PET activity between acquisitions with and without simultaneous 13C-MRSI was 0.83 (largest sphere) and −0.76 % (background). The average difference in net trues was −0.01 %. The average difference in 13C-MRSI SNR between acquisitions with and without simultaneous PET ranged from −2.28 to 1.21 % for all phantoms and measurement conditions. No differences were significant. The system was capable of 13C-MRSI of hyperpolarized 13C-pyruvate. Conclusions: Simultaneous PET and 13C-MRSI in an integrated whole-body PET/MRI hybrid scanner is feasible. Phantom experiments showed that possible interference effects introduced by acquiring data from the two modalities simultaneously are
small and non-significant. Further experiments can now investigate the benefits of simultaneous PET and hyperpolarized 13C-MRI in vivo studies.

Original language	English
Journal	E J N M M I Physics
Volume	3
Issue number	1
Pages (from-to)	1-13
ISSN	2197-7364
DOIs	https://doi.org/10.1186/s40658-016-0143-6
Publication status	Published - 2016

Bibliographical note

© 2016 Hansen et al. Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Medicine & Public Health
Nuclear Medicine
Imaging / Radiology
Applied and Technical Physics
Computational Mathematics and Numerical Analysis
Engineering, general
SC11
PET/MRI
13C magnetic resonance spectroscopic imaging
Hyperpolarization
Quantification
Interference

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@article{959de7e964cf40aab764ab5011b90e0c,

title = "Simultaneous PET/MRI with 13C magnetic resonance spectroscopic imaging (hyperPET): phantom-based evaluation of PET quantification",

abstract = "Background: Integrated PET/MRI with hyperpolarized 13C magnetic resonance spectroscopic imaging (13C-MRSI) offers simultaneous, dual-modality metabolic imaging. A prerequisite for the use of simultaneous imaging is the absence of interference between the two modalities. This has been documented for a clinical whole-body system using simultaneous 1 H-MRI and PET but never for 13C-MRSI and PET. Here, the feasibility of simultaneous PET and 13C-MRSI as well as hyperpolarized 13C-MRSI in an integrated whole-body PET/MRI hybrid scanner is evaluated using phantom experiments. Methods: Combined PET and 13C-MRSI phantoms including a NEMA [18F]-FDG phantom, 13C-acetate and 13C-urea sources, and hyperpolarized 13C-pyruvate were imaged repeatedly with PET and/or 13C-MRSI. Measurements evaluated for interference effects included PET activity values in the largest sphere and a background region; total number of PET trues; and 13C-MRSI signal-to-noise ratio (SNR) for urea and acetate phantoms. Differences between measurement conditions were evaluated using t tests. Results: PET and 13C-MRSI data acquisition could be performed simultaneously without any discernible artifacts. The average difference in PET activity between acquisitions with and without simultaneous 13C-MRSI was 0.83 (largest sphere) and −0.76 \% (background). The average difference in net trues was −0.01 \%. The average difference in 13C-MRSI SNR between acquisitions with and without simultaneous PET ranged from −2.28 to 1.21 \% for all phantoms and measurement conditions. No differences were significant. The system was capable of 13C-MRSI of hyperpolarized 13C-pyruvate. Conclusions: Simultaneous PET and 13C-MRSI in an integrated whole-body PET/MRI hybrid scanner is feasible. Phantom experiments showed that possible interference effects introduced by acquiring data from the two modalities simultaneously are small and non-significant. Further experiments can now investigate the benefits of simultaneous PET and hyperpolarized 13C-MRI in vivo studies.",

keywords = "Medicine \& Public Health, Nuclear Medicine, Imaging / Radiology, Applied and Technical Physics, Computational Mathematics and Numerical Analysis, Engineering, general, SC11, PET/MRI, 13C magnetic resonance spectroscopic imaging, Hyperpolarization, Quantification, Interference",

author = "Hansen, \{Adam E.\} and Andersen, \{Flemming L.\} and Henriksen, \{Sarah T.\} and Alexandre Vignaud and Ardenkj{\ae}r-Larsen, \{Jan Henrik\} and Liselotte H{\o}jgaard and Andreas Kj{\ae}r and Klausen, \{Thomas L.\}",

note = "{\textcopyright} 2016 Hansen et al. Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.",

year = "2016",

doi = "10.1186/s40658-016-0143-6",

language = "English",

volume = "3",

pages = "1--13",

journal = "E J N M M I Physics",

issn = "2197-7364",

publisher = "Springer Science and Business Media Deutschland GmbH",

number = "1",

}

TY - JOUR

T1 - Simultaneous PET/MRI with 13C magnetic resonance spectroscopic imaging (hyperPET): phantom-based evaluation of PET quantification

AU - Hansen, Adam E.

AU - Andersen, Flemming L.

AU - Henriksen, Sarah T.

AU - Vignaud, Alexandre

AU - Ardenkjær-Larsen, Jan Henrik

AU - Højgaard, Liselotte

AU - Kjær, Andreas

AU - Klausen, Thomas L.

N1 - © 2016 Hansen et al. Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

PY - 2016

Y1 - 2016

N2 - Background: Integrated PET/MRI with hyperpolarized 13C magnetic resonance spectroscopic imaging (13C-MRSI) offers simultaneous, dual-modality metabolic imaging. A prerequisite for the use of simultaneous imaging is the absence of interference between the two modalities. This has been documented for a clinical whole-body system using simultaneous 1 H-MRI and PET but never for 13C-MRSI and PET. Here, the feasibility of simultaneous PET and 13C-MRSI as well as hyperpolarized 13C-MRSI in an integrated whole-body PET/MRI hybrid scanner is evaluated using phantom experiments. Methods: Combined PET and 13C-MRSI phantoms including a NEMA [18F]-FDG phantom, 13C-acetate and 13C-urea sources, and hyperpolarized 13C-pyruvate were imaged repeatedly with PET and/or 13C-MRSI. Measurements evaluated for interference effects included PET activity values in the largest sphere and a background region; total number of PET trues; and 13C-MRSI signal-to-noise ratio (SNR) for urea and acetate phantoms. Differences between measurement conditions were evaluated using t tests. Results: PET and 13C-MRSI data acquisition could be performed simultaneously without any discernible artifacts. The average difference in PET activity between acquisitions with and without simultaneous 13C-MRSI was 0.83 (largest sphere) and −0.76 % (background). The average difference in net trues was −0.01 %. The average difference in 13C-MRSI SNR between acquisitions with and without simultaneous PET ranged from −2.28 to 1.21 % for all phantoms and measurement conditions. No differences were significant. The system was capable of 13C-MRSI of hyperpolarized 13C-pyruvate. Conclusions: Simultaneous PET and 13C-MRSI in an integrated whole-body PET/MRI hybrid scanner is feasible. Phantom experiments showed that possible interference effects introduced by acquiring data from the two modalities simultaneously are small and non-significant. Further experiments can now investigate the benefits of simultaneous PET and hyperpolarized 13C-MRI in vivo studies.

AB - Background: Integrated PET/MRI with hyperpolarized 13C magnetic resonance spectroscopic imaging (13C-MRSI) offers simultaneous, dual-modality metabolic imaging. A prerequisite for the use of simultaneous imaging is the absence of interference between the two modalities. This has been documented for a clinical whole-body system using simultaneous 1 H-MRI and PET but never for 13C-MRSI and PET. Here, the feasibility of simultaneous PET and 13C-MRSI as well as hyperpolarized 13C-MRSI in an integrated whole-body PET/MRI hybrid scanner is evaluated using phantom experiments. Methods: Combined PET and 13C-MRSI phantoms including a NEMA [18F]-FDG phantom, 13C-acetate and 13C-urea sources, and hyperpolarized 13C-pyruvate were imaged repeatedly with PET and/or 13C-MRSI. Measurements evaluated for interference effects included PET activity values in the largest sphere and a background region; total number of PET trues; and 13C-MRSI signal-to-noise ratio (SNR) for urea and acetate phantoms. Differences between measurement conditions were evaluated using t tests. Results: PET and 13C-MRSI data acquisition could be performed simultaneously without any discernible artifacts. The average difference in PET activity between acquisitions with and without simultaneous 13C-MRSI was 0.83 (largest sphere) and −0.76 % (background). The average difference in net trues was −0.01 %. The average difference in 13C-MRSI SNR between acquisitions with and without simultaneous PET ranged from −2.28 to 1.21 % for all phantoms and measurement conditions. No differences were significant. The system was capable of 13C-MRSI of hyperpolarized 13C-pyruvate. Conclusions: Simultaneous PET and 13C-MRSI in an integrated whole-body PET/MRI hybrid scanner is feasible. Phantom experiments showed that possible interference effects introduced by acquiring data from the two modalities simultaneously are small and non-significant. Further experiments can now investigate the benefits of simultaneous PET and hyperpolarized 13C-MRI in vivo studies.

KW - Medicine & Public Health

KW - Nuclear Medicine

KW - Imaging / Radiology

KW - Applied and Technical Physics

KW - Computational Mathematics and Numerical Analysis

KW - Engineering, general

KW - SC11

KW - PET/MRI

KW - 13C magnetic resonance spectroscopic imaging

KW - Hyperpolarization

KW - Quantification

KW - Interference

U2 - 10.1186/s40658-016-0143-6

DO - 10.1186/s40658-016-0143-6

M3 - Journal article

C2 - 27102632

SN - 2197-7364

VL - 3

SP - 1

EP - 13

JO - E J N M M I Physics

JF - E J N M M I Physics

IS - 1

ER -

Simultaneous PET/MRI with 13C magnetic resonance spectroscopic imaging (hyperPET): phantom-based evaluation of PET quantification

Abstract

Bibliographical note

UN SDGs

Keywords

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