Simultaneous PET/MRI with 13C magnetic resonance spectroscopic imaging (hyperPET): phantom-based evaluation of PET quantification

Adam E. Hansen, Flemming L. Andersen, Sarah T. Henriksen, Alexandre Vignaud, Jan Henrik Ardenkjær-Larsen, Liselotte Højgaard, Andreas Kjær, Thomas L. Klausen

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Abstract

Background: Integrated PET/MRI with hyperpolarized 13C magnetic resonance spectroscopic imaging (13C-MRSI) offers simultaneous, dual-modality metabolic imaging. A prerequisite for the use of simultaneous imaging is the absence of interference between the two modalities. This has been documented for a clinical whole-body system using simultaneous 1 H-MRI and PET but never for 13C-MRSI and PET. Here, the feasibility of simultaneous PET and 13C-MRSI as well as hyperpolarized 13C-MRSI in an integrated whole-body PET/MRI hybrid scanner is evaluated using phantom experiments. Methods: Combined PET and 13C-MRSI phantoms including a NEMA [18F]-FDG phantom, 13C-acetate and 13C-urea sources, and hyperpolarized 13C-pyruvate were imaged repeatedly with PET and/or 13C-MRSI. Measurements evaluated for interference effects included PET activity values in the largest sphere and a background region; total number of PET trues; and 13C-MRSI signal-to-noise ratio (SNR) for urea and acetate phantoms. Differences between measurement conditions were evaluated using t tests. Results: PET and 13C-MRSI data acquisition could be performed simultaneously without any discernible artifacts. The average difference in PET activity between acquisitions with and without simultaneous 13C-MRSI was 0.83 (largest sphere) and −0.76 % (background). The average difference in net trues was −0.01 %. The average difference in 13C-MRSI SNR between acquisitions with and without simultaneous PET ranged from −2.28 to 1.21 % for all phantoms and measurement conditions. No differences were significant. The system was capable of 13C-MRSI of hyperpolarized 13C-pyruvate. Conclusions: Simultaneous PET and 13C-MRSI in an integrated whole-body PET/MRI hybrid scanner is feasible. Phantom experiments showed that possible interference effects introduced by acquiring data from the two modalities simultaneously are
small and non-significant. Further experiments can now investigate the benefits of simultaneous PET and hyperpolarized 13C-MRI in vivo studies.
Original languageEnglish
JournalE J N M M I Physics
Volume3
Issue number1
Pages (from-to)1-13
ISSN2197-7364
DOIs
Publication statusPublished - 2016

Bibliographical note

© 2016 Hansen et al. Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

Keywords

  • Medicine & Public Health
  • Nuclear Medicine
  • Imaging / Radiology
  • Applied and Technical Physics
  • Computational Mathematics and Numerical Analysis
  • Engineering, general
  • SC11
  • PET/MRI
  • 13C magnetic resonance spectroscopic imaging
  • Hyperpolarization
  • Quantification
  • Interference

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