Simultaneous Determination of Binding Constants for Multiple Carbohydrate Hosts in Complex Mixtures

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Abstract

We describe a simple method for the simultaneous determination of association constants for a guest binding to seven different hosts in a mixture of more than 20 different oligosaccharides. If the binding parameters are known for one component in the mixture, a single NMR titration suffices to determine binding constants for all other detectable and resolvable hosts. With the use of high-resolution 1H−13C HSQC experiments, complexes of amphiphiles with more than 10 different maltooligosaccharides can be resolved. Hereby, the binding capabilities of a set of structurally related hosts can be quantitatively studied to systematically explore noncovalent interactions without the need to isolate each
host
Original languageEnglish
JournalJournal of the American Chemical Society
Volume136
Issue number32
Pages (from-to)11284-11287
Number of pages4
ISSN0002-7863
DOIs
Publication statusPublished - 2014

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