A method for t he simultaneous determination of arsenic , copper, manganese, selenium, and zinc in biological materia l was developed by the incorporation of separation procedures for copper and zinc into an existing procedure. Investigation of the performance characteristic s ofthe method was carried out with reference to copper and zinc. For certain materials characterized by a high Cu/Zn ratio, or a high zinc content, or both, such as liver, copper interferes in the determination of zinc thus requiring a small correction by an iterative procedure. Blank values for copper depend on the rinsing ofthe irradiation container, and a single rinsing with redistilled water was found superior to the other rinsing procedures. Nuclear interference was negligible. The accuracy of the method was checked by analysis of Standard Reference Materials and the precision verified by analysis of Intercomparison Samples. Results are presented for 5 male foetuses of 3-5 months' gestational age. The distribution of arsenic , manganese and selenium is similar to that previously reported for adults. With the exception of liver, concentrations of copper in foetal organs were lower than values in the literature indicate.
|Place of Publication||Roskilde, Denmark|
|Publisher||Risø National Laboratory|
|Number of pages||24|
|Publication status||Published - 1976|
|Series||Denmark. Forskningscenter Risoe. Risoe-R|
- Risø report 326