Simulation of microbubble response to ambient pressure changes

Klaus Scheldrup Andersen, Jørgen Arendt Jensen

Research output: Chapter in Book/Report/Conference proceedingArticle in proceedingsResearchpeer-review


The theory on microbubbles clearly indicates a relation between the ambient pressure and the acoustic behavior of the bubble. The purpose of this study was to optimize the sensitivity of ambient pressure measurements, using the subharmonic component, through microbubble response simulations. The behaviour of two different contrast agents was investigated as a function of driving pulse and ambient overpressure, pov. Simulations of Levovist using a rectangular driving pulse show an almost linear reduction in the subharmonic component as pov is increased. For a 20 cycles driving pulse, a reduction of 4.6 dB is observed when changing pov from 0 to 25 kPa. Increasing the pulse duration makes the reduction even more clear. For a pulse with 64 cycles, the reduction is 9.9 dB. This simulation is in good correspondence with measurement results presented by Shi et al. 1999, who found a linear reduction of 9.6 dB. Further simulations of Levovist show that also the shape and the acoustic pressure of the driving pulse are very important factors. The best pressure sensitivity of Levovist was found to be 0.88 dB/kPa. For Sonazoid, a sensitivity of 0.71 dB/kPa has been found, although the reduction is not completely linear as a function of the ambient pressure.
Original languageEnglish
Title of host publicationMedical Imaging 2008 : Ultrasonic Imaging and Signal Processing
Number of pages12
Publication date2008
PagesArticle number: 92016
ISBN (Print)978-0-8194-7104-8
Publication statusPublished - 2008
EventSPIE Medical Imaging 2008: Ultrasonic Imaging and Signal Processing - San Diego, United States
Duration: 17 Feb 200818 Feb 2008
Conference number: 6920


ConferenceSPIE Medical Imaging 2008
Country/TerritoryUnited States
CitySan Diego
SeriesProceedings of S P I E - International Society for Optical Engineering


  • Ultrasound contrast agent
  • Simulation of microbubbles
  • Ambient pressure estimation


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