Simplified Monolithic Flow Cytometer Chip With Three-Dimensional Hydrodyanmic Focusing And Integrated Fiber-Free Optics

Masahiro  Motosuke; Thomas Glasdam Jensen; Guisheng Zhuang; Jörg Peter Kutter

Simplified Monolithic Flow Cytometer Chip With Three-Dimensional Hydrodyanmic Focusing And Integrated Fiber-Free Optics

Masahiro Motosuke
, Thomas Glasdam Jensen
, Guisheng Zhuang
, Jörg Peter Kutter

Tokyo University of Science

Research output: Chapter in Book/Report/Conference proceeding › Article in proceedings › Research › peer-review

Abstract

A miniaturized flow cytometry incorporating both fluidic and optical systems has a great possibility for portable
biochemical sensing or point-of-care diagnostics. This paper presents a simple microfluidic flow cytometer combining
reliable 3D hydrodynamic focusing and optical detection without optical fibers in a monolithic architecture fabricated by a
single photolithographic process. The vertical flow focusing is achieved by the optimized inlet geometry in a PDMS lid onto
the substrate with detection channel and integrated optics. The simplified approach indicates the possibility to be applied as a
portable platform of cytometer chip.

Original language	English
Title of host publication	Proceedings of 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences
Publication date	2011
Pages	1888-1890
Publication status	Published - 2011
Event	15th International Conference on Miniaturized Systems for Chemistry and Life Sciences - Seattle, United States Duration: 2 Oct 2011 → 6 Oct 2011 Conference number: 15 https://microtasconferences.org/microtas2011/

Conference

Conference	15th International Conference on Miniaturized Systems for Chemistry and Life Sciences
Number	15
Country/Territory	United States
City	Seattle
Period	02/10/2011 → 06/10/2011
Internet address	https://microtasconferences.org/microtas2011/

Keywords

Flow cytometry
Hydrodynamic focusing
Integrated optics
Particle detection

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@inproceedings{b37ce10599594feb9f385afd9b03e24d,

title = "Simplified Monolithic Flow Cytometer Chip With Three-Dimensional Hydrodyanmic Focusing And Integrated Fiber-Free Optics",

abstract = "A miniaturized flow cytometry incorporating both fluidic and optical systems has a great possibility for portable biochemical sensing or point-of-care diagnostics. This paper presents a simple microfluidic flow cytometer combining reliable 3D hydrodynamic focusing and optical detection without optical fibers in a monolithic architecture fabricated by a single photolithographic process. The vertical flow focusing is achieved by the optimized inlet geometry in a PDMS lid onto the substrate with detection channel and integrated optics. The simplified approach indicates the possibility to be applied as a portable platform of cytometer chip.",

keywords = "Flow cytometry, Hydrodynamic focusing, Integrated optics, Particle detection",

author = "Masahiro Motosuke and Jensen, \{Thomas Glasdam\} and Guisheng Zhuang and Kutter, \{J{\"o}rg Peter\}",

year = "2011",

language = "English",

pages = "1888--1890",

booktitle = "Proceedings of 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences",

note = "15th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2011 ; Conference date: 02-10-2011 Through 06-10-2011",

url = "https://microtasconferences.org/microtas2011/",

}

Motosuke, M, Jensen, TG, Zhuang, G & Kutter, JP 2011, Simplified Monolithic Flow Cytometer Chip With Three-Dimensional Hydrodyanmic Focusing And Integrated Fiber-Free Optics. in Proceedings of 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences. pp. 1888-1890, 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences, Seattle, Washington, United States, 02/10/2011.

Simplified Monolithic Flow Cytometer Chip With Three-Dimensional Hydrodyanmic Focusing And Integrated Fiber-Free Optics. / Motosuke, Masahiro ; Jensen, Thomas Glasdam; Zhuang, Guisheng et al.
Proceedings of 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences. 2011. p. 1888-1890.

Research output: Chapter in Book/Report/Conference proceeding › Article in proceedings › Research › peer-review

TY - GEN

T1 - Simplified Monolithic Flow Cytometer Chip With Three-Dimensional Hydrodyanmic Focusing And Integrated Fiber-Free Optics

AU - Motosuke, Masahiro

AU - Jensen, Thomas Glasdam

AU - Zhuang, Guisheng

AU - Kutter, Jörg Peter

N1 - Conference code: 15

PY - 2011

Y1 - 2011

N2 - A miniaturized flow cytometry incorporating both fluidic and optical systems has a great possibility for portable biochemical sensing or point-of-care diagnostics. This paper presents a simple microfluidic flow cytometer combining reliable 3D hydrodynamic focusing and optical detection without optical fibers in a monolithic architecture fabricated by a single photolithographic process. The vertical flow focusing is achieved by the optimized inlet geometry in a PDMS lid onto the substrate with detection channel and integrated optics. The simplified approach indicates the possibility to be applied as a portable platform of cytometer chip.

AB - A miniaturized flow cytometry incorporating both fluidic and optical systems has a great possibility for portable biochemical sensing or point-of-care diagnostics. This paper presents a simple microfluidic flow cytometer combining reliable 3D hydrodynamic focusing and optical detection without optical fibers in a monolithic architecture fabricated by a single photolithographic process. The vertical flow focusing is achieved by the optimized inlet geometry in a PDMS lid onto the substrate with detection channel and integrated optics. The simplified approach indicates the possibility to be applied as a portable platform of cytometer chip.

KW - Flow cytometry

KW - Hydrodynamic focusing

KW - Integrated optics

KW - Particle detection

M3 - Article in proceedings

SP - 1888

EP - 1890

BT - Proceedings of 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences

T2 - 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences

Y2 - 2 October 2011 through 6 October 2011

ER -

Simplified Monolithic Flow Cytometer Chip With Three-Dimensional Hydrodyanmic Focusing And Integrated Fiber-Free Optics

Abstract

Conference

Keywords

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