Simplified Monolithic Flow Cytometer Chip With Three-Dimensional Hydrodyanmic Focusing And Integrated Fiber-Free Optics

Masahiro Motosuke, Thomas Glasdam Jensen, Guisheng Zhuang, Jörg Peter Kutter

    Research output: Chapter in Book/Report/Conference proceedingArticle in proceedingsResearchpeer-review

    Abstract

    A miniaturized flow cytometry incorporating both fluidic and optical systems has a great possibility for portable
    biochemical sensing or point-of-care diagnostics. This paper presents a simple microfluidic flow cytometer combining
    reliable 3D hydrodynamic focusing and optical detection without optical fibers in a monolithic architecture fabricated by a
    single photolithographic process. The vertical flow focusing is achieved by the optimized inlet geometry in a PDMS lid onto
    the substrate with detection channel and integrated optics. The simplified approach indicates the possibility to be applied as a
    portable platform of cytometer chip.
    Original languageEnglish
    Title of host publicationProceedings of 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences
    Publication date2011
    Pages1888-1890
    Publication statusPublished - 2011
    Event15th International Conference on Miniaturized Systems for Chemistry and Life Sciences - Seattle, WA, United States
    Duration: 2 Oct 20116 Oct 2011
    http://www.microtas2011.org/

    Conference

    Conference15th International Conference on Miniaturized Systems for Chemistry and Life Sciences
    CountryUnited States
    CitySeattle, WA
    Period02/10/201106/10/2011
    Internet address

    Keywords

    • Flow cytometry
    • Hydrodynamic focusing
    • Integrated optics
    • Particle detection

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