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Abstract
We want to implement two-photon excitation fluorescence microscopy (TPEFM) into endoscopes, since TPEFM can provide relevant biomarkers for cancer staging and grading in hollow organs, endoscopically accessible through natural orifices. However, many obstacles must be overcome, among others the delivery of short laser
pulses to the distal end of the endoscope. To this avail, we present imaging results using an all-fibre dispersion management scheme in a TPEFM setup. The scheme has been conceived by Jespersen et al. in 20101 and relies on the combination of a single mode fibre with normal and a higher order mode fibre with anomalous dispersion properties, fused in series using a long period grating. We show that using this fibre assembly, a simple and robust pulsed laser delivery system without any free-space optics, which is thus suitable for clinical use, can be realised.
pulses to the distal end of the endoscope. To this avail, we present imaging results using an all-fibre dispersion management scheme in a TPEFM setup. The scheme has been conceived by Jespersen et al. in 20101 and relies on the combination of a single mode fibre with normal and a higher order mode fibre with anomalous dispersion properties, fused in series using a long period grating. We show that using this fibre assembly, a simple and robust pulsed laser delivery system without any free-space optics, which is thus suitable for clinical use, can be realised.
Original language | English |
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Title of host publication | Proceedings of SPIE |
Number of pages | 8 |
Publisher | SPIE - International Society for Optical Engineering |
Publication date | 2018 |
DOIs | |
Publication status | Published - 2018 |
Event | SPIE Photonics West 2018: Multiphoton Microscopy in the Biomedical Sciences XVIII - Moscone Center, San Francisco, United States Duration: 27 Jan 2018 → 1 Feb 2018 Conference number: 10498 https://spie.org/PWB/conferencedetails/multiphoton-microscopy |
Conference
Conference | SPIE Photonics West 2018 |
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Number | 10498 |
Location | Moscone Center |
Country/Territory | United States |
City | San Francisco |
Period | 27/01/2018 → 01/02/2018 |
Internet address |
Series | Proceedings of SPIE - The International Society for Optical Engineering |
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ISSN | 0277-786X |
Keywords
- Two-photon microscopy
- Femtosecond laser pulse
- Dispersion management
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Dive into the research topics of 'Simple fibre based dispersion management for two-photon excited fluorescence imaging through an endoscope'. Together they form a unique fingerprint.Projects
- 1 Finished
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MIB: Multi-modal, Endoscopic Biophotonic Imaging of Bladder Cancer for Point-of-Care Diagnosis
Marti, D., Hansen, A. K., Jensen, O. B. & Andersen, P. E.
01/01/2016 → 31/12/2021
Project: Research