Simple estimate of the influence of competitive inhibition on PBTK based risk assessment

Trine Klein Reffstrup, Annette Petersen, Elsa Nielsen, Svava Osk Jonsdottir

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Abstract

Background: In recent years, increased focus has been on the development of methods for assessing health risks caused by exposure to mixtures of chemicals from food and the environment. It has been recommended by international bodies to consider physiologically based toxicokinetic (PBTK) modelling for higher tier cumulative risk assessment of
chemicals. Another important area for the use of PBTK is risk assessment of aggregate exposure via different routes (dietary, dermal, etc.).
Original languageEnglish
Publication date2014
Number of pages1
Publication statusPublished - 2014
Event50th Congress of the European Societies of Toxicology (EUROTOX) - Edinburgh International Conference Centre, Edinburgh, United Kingdom
Duration: 7 Sept 201410 Sept 2014
Conference number: 50

Conference

Conference50th Congress of the European Societies of Toxicology (EUROTOX)
Number50
Location Edinburgh International Conference Centre
Country/TerritoryUnited Kingdom
CityEdinburgh
Period07/09/201410/09/2014

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