TY - JOUR
T1 - Simple Aziridino Alcohols as Chiral Ligands. Enantioselective Additions of Diethylzinc to N-Diphenylphosphinoylimines.
AU - Tanner, David Ackland
AU - Andersson, Pher G.
AU - Guijarro, David
PY - 1996
Y1 - 1996
N2 - Simple chiral aziridino alcohols 2-5, easily available from L-serine, L-threonine or L-allo-threonine, have been used as ligands to promote the addition of Et(2)Zn to the diphenylphosphinoylimine 1 (Ar=Ph). Enantioselectivities of up to 94% could be obtained by proper choice of the substituents on the ligand. Up to 90% of the ligand could be recovered during the work-up. The use of ligand 3a as catalyst for the same reaction has also been studied.
AB - Simple chiral aziridino alcohols 2-5, easily available from L-serine, L-threonine or L-allo-threonine, have been used as ligands to promote the addition of Et(2)Zn to the diphenylphosphinoylimine 1 (Ar=Ph). Enantioselectivities of up to 94% could be obtained by proper choice of the substituents on the ligand. Up to 90% of the ligand could be recovered during the work-up. The use of ligand 3a as catalyst for the same reaction has also been studied.
M3 - Journal article
SN - 0936-5214
SP - 727
EP - 728
JO - SYNLETT: Accounts and Rapid Communications in Chemical Synthesis
JF - SYNLETT: Accounts and Rapid Communications in Chemical Synthesis
IS - 8
ER -