Silver/poly (lactic acid) nanocomposites: Preparation, characterization, and antibacterial activity

Kamyar Shameli, Mansor Bin Ahmad, Wan Md Zin Wan Yunus, Nor Azowa Ibrahim, Russly Abdul Rahman, Maryam Jokar, Majid Darroudi

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In this study, antibacterial characteristic of silver/poly (lactic acid) nanocomposite (Ag/PLA-NC) films was investigated, while silver nanoparticles (Ag-NPs) were synthesized into biodegradable PLA via chemical reduction method in diphase solvent. Silver nitrate and sodium borohydride were respectively used as a silver precursor and reducing agent in the PLA, which acted as a polymeric matrix and stabilizer. Meanwhile, the properties of Ag/PLA-NCs were studied as a function of the Ag-NP weight percentages (8, 16, and 32 wt% respectively), in relation to the use of PLA. The morphology of the Ag/PLA-NC films and the distribution of the Ag-NPs were also characterized. The silver ions released from the Ag/PLA-NC films and their antibacterial activities were scrutinized. The antibacterial activities of the Ag/PLA-NC films were examined against Gram-negative bacteria (Escherichia coli and Vibrio parahaemolyticus) and Gram-positive bacteria (Staphylococcus aureus) by diffusion method using Muller-Hinton agar. The results indicated that Ag/PLA-NC films possessed a strong antibacterial activity with the increase in the percentage of Ag-NPs in the PLA. Thus, Ag/PLA-NC films can be used as an antibacterial scaffold for tissue engineering and medical application. �� 2010 Shameli et al, publisher and licensee Dove Medical Press Ltd.
Original languageEnglish
JournalInternational Journal of Nanomedicine (Online)
Issue number1
Pages (from-to)573-579
Publication statusPublished - 2010
Externally publishedYes

Bibliographical note

© 2010 Shameli et al, publisher and licensee Dove Medical Press Ltd. This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.


  • Biophysics
  • Bioengineering
  • Biomaterials
  • Organic Chemistry
  • Drug Discovery
  • Antibacterial activity
  • Biodegradable
  • Muller-Hinton agar
  • Poly (lactic acid)
  • Silver nanoparticles
  • lactic acid
  • molecular scaffold
  • silver nanoparticle
  • sodium borohydride
  • antiinfective agent
  • metal nanoparticle
  • nanocomposite
  • silver
  • tissue scaffold
  • agar diffusion
  • antibacterial activity
  • article
  • biodegradability
  • chemical structure
  • controlled study
  • Escherichia coli
  • infrared spectroscopy
  • materials testing
  • molecular weight
  • nonhuman
  • reduction kinetics
  • solvent effect
  • Staphylococcus aureus
  • tissue engineering
  • ultraviolet spectroscopy
  • Vibrio parahaemolyticus
  • X ray diffraction
  • chemistry
  • drug effect
  • microbiological examination
  • nanomedicine
  • particle size
  • spectrophotometry
  • transmission electron microscopy
  • ultrastructure
  • Negibacteria
  • Posibacteria
  • Anti-Bacterial Agents
  • Metal Nanoparticles
  • Microbial Sensitivity Tests
  • Microscopy, Electron, Transmission
  • Nanocomposites
  • Nanomedicine
  • Particle Size
  • Silver
  • Spectrophotometry
  • Spectroscopy, Fourier Transform Infrared
  • Tissue Scaffolds
  • X-Ray Diffraction


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