Silver/poly (lactic acid) nanocomposites: Preparation, characterization, and antibacterial activity

Kamyar Shameli; Mansor Bin Ahmad; Wan Md Zin Wan Yunus; Nor Azowa Ibrahim; Russly Abdul Rahman; Maryam Jokar; Majid Darroudi

doi:10.2147/ijn.s12007

Silver/poly (lactic acid) nanocomposites: Preparation, characterization, and antibacterial activity

Kamyar Shameli, Mansor Bin Ahmad, Wan Md Zin Wan Yunus, Nor Azowa Ibrahim, Russly Abdul Rahman, Maryam Jokar, Majid Darroudi

Universiti Putra Malaysia

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Abstract

In this study, antibacterial characteristic of silver/poly (lactic acid) nanocomposite (Ag/PLA-NC) films was investigated, while silver nanoparticles (Ag-NPs) were synthesized into biodegradable PLA via chemical reduction method in diphase solvent. Silver nitrate and sodium borohydride were respectively used as a silver precursor and reducing agent in the PLA, which acted as a polymeric matrix and stabilizer. Meanwhile, the properties of Ag/PLA-NCs were studied as a function of the Ag-NP weight percentages (8, 16, and 32 wt% respectively), in relation to the use of PLA. The morphology of the Ag/PLA-NC films and the distribution of the Ag-NPs were also characterized. The silver ions released from the Ag/PLA-NC films and their antibacterial activities were scrutinized. The antibacterial activities of the Ag/PLA-NC films were examined against Gram-negative bacteria (Escherichia coli and Vibrio parahaemolyticus) and Gram-positive bacteria (Staphylococcus aureus) by diffusion method using Muller-Hinton agar. The results indicated that Ag/PLA-NC films possessed a strong antibacterial activity with the increase in the percentage of Ag-NPs in the PLA. Thus, Ag/PLA-NC films can be used as an antibacterial scaffold for tissue engineering and medical application.

Original language	English
Journal	International Journal of Nanomedicine (Online)
Volume	5
Issue number	1
Pages (from-to)	573-579
ISSN	1176-9114
DOIs	https://doi.org/10.2147/ijn.s12007
Publication status	Published - 2010
Externally published	Yes

Bibliographical note

Keywords

Biophysics
Bioengineering
Biomaterials
Organic Chemistry
Drug Discovery
Antibacterial activity
Biodegradable
Muller-Hinton agar
Poly (lactic acid)
Silver nanoparticles
lactic acid
molecular scaffold
silver nanoparticle
sodium borohydride
antiinfective agent
metal nanoparticle
nanocomposite
silver
tissue scaffold
agar diffusion
antibacterial activity
article
biodegradability
chemical structure
controlled study
Escherichia coli
infrared spectroscopy
materials testing
molecular weight
nonhuman
reduction kinetics
solvent effect
Staphylococcus aureus
tissue engineering
ultraviolet spectroscopy
Vibrio parahaemolyticus
X ray diffraction
chemistry
drug effect
microbiological examination
nanomedicine
particle size
spectrophotometry
transmission electron microscopy
ultrastructure
Negibacteria
Posibacteria
Anti-Bacterial Agents
Metal Nanoparticles
Microbial Sensitivity Tests
Microscopy, Electron, Transmission
Nanocomposites
Nanomedicine
Particle Size
Silver
Spectrophotometry
Spectroscopy, Fourier Transform Infrared
Tissue Scaffolds
X-Ray Diffraction

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title = "Silver/poly (lactic acid) nanocomposites: Preparation, characterization, and antibacterial activity",

abstract = "In this study, antibacterial characteristic of silver/poly (lactic acid) nanocomposite (Ag/PLA-NC) films was investigated, while silver nanoparticles (Ag-NPs) were synthesized into biodegradable PLA via chemical reduction method in diphase solvent. Silver nitrate and sodium borohydride were respectively used as a silver precursor and reducing agent in the PLA, which acted as a polymeric matrix and stabilizer. Meanwhile, the properties of Ag/PLA-NCs were studied as a function of the Ag-NP weight percentages (8, 16, and 32 wt% respectively), in relation to the use of PLA. The morphology of the Ag/PLA-NC films and the distribution of the Ag-NPs were also characterized. The silver ions released from the Ag/PLA-NC films and their antibacterial activities were scrutinized. The antibacterial activities of the Ag/PLA-NC films were examined against Gram-negative bacteria (Escherichia coli and Vibrio parahaemolyticus) and Gram-positive bacteria (Staphylococcus aureus) by diffusion method using Muller-Hinton agar. The results indicated that Ag/PLA-NC films possessed a strong antibacterial activity with the increase in the percentage of Ag-NPs in the PLA. Thus, Ag/PLA-NC films can be used as an antibacterial scaffold for tissue engineering and medical application.",

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author = "Kamyar Shameli and Ahmad, {Mansor Bin} and {Md Zin Wan Yunus}, Wan and Ibrahim, {Nor Azowa} and Rahman, {Russly Abdul} and Maryam Jokar and Majid Darroudi",

note = "{\textcopyright} 2010 Shameli et al, publisher and licensee Dove Medical Press Ltd. This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.",

year = "2010",

doi = "10.2147/ijn.s12007",

language = "English",

volume = "5",

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T1 - Silver/poly (lactic acid) nanocomposites: Preparation, characterization, and antibacterial activity

AU - Shameli, Kamyar

AU - Ahmad, Mansor Bin

AU - Md Zin Wan Yunus, Wan

AU - Ibrahim, Nor Azowa

AU - Rahman, Russly Abdul

AU - Jokar, Maryam

AU - Darroudi, Majid

PY - 2010

Y1 - 2010

N2 - In this study, antibacterial characteristic of silver/poly (lactic acid) nanocomposite (Ag/PLA-NC) films was investigated, while silver nanoparticles (Ag-NPs) were synthesized into biodegradable PLA via chemical reduction method in diphase solvent. Silver nitrate and sodium borohydride were respectively used as a silver precursor and reducing agent in the PLA, which acted as a polymeric matrix and stabilizer. Meanwhile, the properties of Ag/PLA-NCs were studied as a function of the Ag-NP weight percentages (8, 16, and 32 wt% respectively), in relation to the use of PLA. The morphology of the Ag/PLA-NC films and the distribution of the Ag-NPs were also characterized. The silver ions released from the Ag/PLA-NC films and their antibacterial activities were scrutinized. The antibacterial activities of the Ag/PLA-NC films were examined against Gram-negative bacteria (Escherichia coli and Vibrio parahaemolyticus) and Gram-positive bacteria (Staphylococcus aureus) by diffusion method using Muller-Hinton agar. The results indicated that Ag/PLA-NC films possessed a strong antibacterial activity with the increase in the percentage of Ag-NPs in the PLA. Thus, Ag/PLA-NC films can be used as an antibacterial scaffold for tissue engineering and medical application.

AB - In this study, antibacterial characteristic of silver/poly (lactic acid) nanocomposite (Ag/PLA-NC) films was investigated, while silver nanoparticles (Ag-NPs) were synthesized into biodegradable PLA via chemical reduction method in diphase solvent. Silver nitrate and sodium borohydride were respectively used as a silver precursor and reducing agent in the PLA, which acted as a polymeric matrix and stabilizer. Meanwhile, the properties of Ag/PLA-NCs were studied as a function of the Ag-NP weight percentages (8, 16, and 32 wt% respectively), in relation to the use of PLA. The morphology of the Ag/PLA-NC films and the distribution of the Ag-NPs were also characterized. The silver ions released from the Ag/PLA-NC films and their antibacterial activities were scrutinized. The antibacterial activities of the Ag/PLA-NC films were examined against Gram-negative bacteria (Escherichia coli and Vibrio parahaemolyticus) and Gram-positive bacteria (Staphylococcus aureus) by diffusion method using Muller-Hinton agar. The results indicated that Ag/PLA-NC films possessed a strong antibacterial activity with the increase in the percentage of Ag-NPs in the PLA. Thus, Ag/PLA-NC films can be used as an antibacterial scaffold for tissue engineering and medical application.

KW - Biophysics

KW - Bioengineering

KW - Biomaterials

KW - Organic Chemistry

KW - Drug Discovery

KW - Antibacterial activity

KW - Biodegradable

KW - Muller-Hinton agar

KW - Poly (lactic acid)

KW - Silver nanoparticles

KW - lactic acid

KW - molecular scaffold

KW - silver nanoparticle

KW - sodium borohydride

KW - antiinfective agent

KW - metal nanoparticle

KW - nanocomposite

KW - silver

KW - tissue scaffold

KW - agar diffusion

KW - antibacterial activity

KW - article

KW - biodegradability

KW - chemical structure

KW - controlled study

KW - Escherichia coli

KW - infrared spectroscopy

KW - materials testing

KW - molecular weight

KW - nonhuman

KW - reduction kinetics

KW - solvent effect

KW - Staphylococcus aureus

KW - tissue engineering

KW - ultraviolet spectroscopy

KW - Vibrio parahaemolyticus

KW - X ray diffraction

KW - chemistry

KW - drug effect

KW - microbiological examination

KW - nanomedicine

KW - particle size

KW - spectrophotometry

KW - transmission electron microscopy

KW - ultrastructure

KW - Negibacteria

KW - Posibacteria

KW - Anti-Bacterial Agents

KW - Metal Nanoparticles

KW - Microbial Sensitivity Tests

KW - Microscopy, Electron, Transmission

KW - Nanocomposites

KW - Nanomedicine

KW - Particle Size

KW - Silver

KW - Spectrophotometry

KW - Spectroscopy, Fourier Transform Infrared

KW - Tissue Scaffolds

KW - X-Ray Diffraction

U2 - 10.2147/ijn.s12007

DO - 10.2147/ijn.s12007

M3 - Journal article

SN - 1176-9114

VL - 5

SP - 573

EP - 579

JO - International Journal of Nanomedicine (Online)

JF - International Journal of Nanomedicine (Online)

IS - 1

ER -

Silver/poly (lactic acid) nanocomposites: Preparation, characterization, and antibacterial activity

Abstract

Bibliographical note

Keywords

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