Abstract
Silicone transdermal drug delivery patches have potential applications in skin care products, providing a promising approach for administrating active ingredients and drugs directly through the skin. However, due to the protective barrier function of the outermost layer of the skin, the penetration of most actives into the deeper layers of the skin is limited. To address this, two-phase glycerol-silicone biocompatible skin cure patches have been investigated, offering substance release capabilities, while ensuring a comfortable and gentle adaptation to the skin [1]. One of the main challenges of achieving efficacy with such transdermal drug delivery systems lies in their design, involving the selection of compatible active ingredients and their efficient absorption within the matrix.
In this study, we compared the efficacy and stability of two glycerol-silicone skin cure formulations containing different hyaluronic acids and vitamin C. A clinical trial was conducted with 8 subjects, where the two different glycerol-silicon skin cure formulations were placed on the forearm for 8 days and 18 hours per day. Ultrasound imaging of the skin was conducted along with assessment of other skin properties, such as hydration, viscoelasticity and transepidermal water loss. Efficacy of the glycerol-silicone skin cure formulations in improving skin properties was demonstrated.
In this study, we compared the efficacy and stability of two glycerol-silicone skin cure formulations containing different hyaluronic acids and vitamin C. A clinical trial was conducted with 8 subjects, where the two different glycerol-silicon skin cure formulations were placed on the forearm for 8 days and 18 hours per day. Ultrasound imaging of the skin was conducted along with assessment of other skin properties, such as hydration, viscoelasticity and transepidermal water loss. Efficacy of the glycerol-silicone skin cure formulations in improving skin properties was demonstrated.
| Original language | English |
|---|---|
| Publication date | 2023 |
| Number of pages | 1 |
| Publication status | Published - 2023 |
| Event | 10th European Silicon Days - Ecole Nationale Supérieure de Chimie de Montpellier, Montpellier, France Duration: 10 Jul 2023 → 12 Jul 2023 Conference number: 10 https://10esd.sciencesconf.org/ |
Conference
| Conference | 10th European Silicon Days |
|---|---|
| Number | 10 |
| Location | Ecole Nationale Supérieure de Chimie de Montpellier |
| Country/Territory | France |
| City | Montpellier |
| Period | 10/07/2023 → 12/07/2023 |
| Internet address |