Signatures of selection and environmental adaptation across the goat genome post‑domestication

Research output: Contribution to journalJournal article – Annual report year: 2018Researchpeer-review

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  • Author: Bertolini, Francesca

    Iowa State University

    Section for Marine Living Resources, National Institute of Aquatic Resources, Technical University of Denmark, Kemitorvet, 2800, Kgs. Lyngby, Denmark

  • Author: Servin, Bertrand

    Universite de Toulouse, France

  • Author: Talenti, Andrea

    University of Milan, Italy

  • Author: Rochat, Estelle

    Swiss Federal Institute of Technology Lausanne, Switzerland

  • Author: Kim, Eui Soo

    Recombinetics Inc, United States

  • Author: Oget, Claire

    Universite de Toulouse, France

  • Author: Palhière, Isabelle

    Universite de Toulouse, France

  • Author: Crisà, Alessandra

    Research Centre for Animal Production and Aquaculture, Italy

  • Author: Catillo, Gennaro

    Research Centre for Animal Production and Aquaculture, Italy

  • Author: Steri, Roberto

    Research Centre for Animal Production and Aquaculture, Italy

  • Author: Amills, Marcel

    Autonomous University of Barcelona, Spain

  • Author: Colli, Licia

    Catholic University of the Sacred Heart

  • Author: Marras, Gabriele

    Fondazione Parco Tecnologico Padano

  • Author: Milanesi, Marco

    Catholic University of the Sacred Heart

  • Author: Nicolazzi, Ezequiel Luis

    Fondazione Parco Tecnologico Padano, Italy

  • Author: Rosen, Benjamin D.

    United States Department of Agriculture, United States

  • Author: Van Tassell, Curtis P.

    United States Department of Agriculture, United States

  • Author: Guldbrandtsen, Bernt

    Aarhus University, Denmark

  • Author: Sonstegard, Tad S.

    Recombinetics Inc, United States

  • Author: Tosser-Klopp, Gwenola

    Universite de Toulouse, France

  • Author: Stella, Alessandra

    Catholic University of the Sacred Heart, Italy

  • Author: Rothschild, Max F.

    Iowa State University, United States

  • Author: Joost, Stéphane

    Swiss Federal Institute of Technology Lausanne, Switzerland

  • Author: Crepaldi, Paola

    University of Milan, Italy

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Background: Since goat was domesticated 10,000 years ago, many factors have contributed to the differentiation of goat breeds and these are classified mainly into two types: (i) adaptation to different breeding systems and/or purposes and (ii) adaptation to different environments. As a result, approximately 600 goat breeds have developed worldwide; they differ considerably from one another in terms of phenotypic characteristics and are adapted to a wide range of climatic conditions. In this work, we analyzed the AdaptMap goat dataset, which is composed of data from more than 3000 animals collected worldwide and genotyped with the CaprineSNP50 BeadChip. These animals were partitioned into groups based on geographical area, production uses, available records on solid coat color and environmental variables including the sampling geographical coordinates, to investigate the role of natural and/or artificial selection in shaping the genome of goat breeds. Results: Several signatures of selection on different chromosomal regions were detected across the different breeds, sub-geographical clusters, phenotypic and climatic groups. These regions contain genes that are involved in important biological processes, such as milk-, meat- or fiber-related production, coat color, glucose pathway, oxidative stress response, size, and circadian clock differences. Our results confirm previous findings in other species on adaptation to extreme environments and human purposes and provide new genes that could explain some of the differences between goat breeds according to their geographical distribution and adaptation to different environments. Conclusions: These analyses of signatures of selection provide a comprehensive first picture of the global domestication process and adaptation of goat breeds and highlight possible genes that may have contributed to the differentiation of this species worldwide.

Original languageEnglish
Article number57
JournalGenetics Selection Evolution
Volume50
Issue number1
ISSN0999-193X
DOIs
Publication statusPublished - 19 Nov 2018
CitationsWeb of Science® Times Cited: No match on DOI
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