SignalP: The Evolution of a Web Server

Henrik Nielsen, Felix Teufel, Søren Brunak, Gunnar von Heijne

Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

Abstract

SignalP ( https://services.healthtech.dtu.dk/services/SignalP-6.0/ ) is a very popular prediction method for signal peptides, the intrinsic signals that make proteins secretory. The SignalP web server has existed since 1995 and is now in its sixth major version. In this historical account, we (three authors who have taken part in the entire journey plus the first author of the latest version) describe the differences between the versions and discuss the various decisions taken along the way.

Original languageEnglish
Title of host publicationProtein Bioinformatics
Volume2836
PublisherSpringer
Publication date2024
Pages331-367
Chapter17
DOIs
Publication statusPublished - 2024
SeriesMethods in molecular biology (Clifton, N.J.)
Volume2836
ISSN1064-3745

Keywords

  • Hidden Markov model
  • Neural network
  • Protein language model
  • Signal peptide

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