TY - JOUR
T1 - SHORT-TERM TOXICITY STUDY IN RATS DOSED WITH PEPPERMINT OIL
AU - Thorup, I.
AU - Würtzen, G.
AU - Carstensen, J.
AU - Olsen, P.
PY - 1983
Y1 - 1983
N2 - Pulegone and menthol, components of peppermint oil, were investigated in rats. The substances were administered by gavage for 28 days at 0, 20, 80, 160 mg pulegone and 0, 200, 400, 800 mg menthol/kg body wt./day, respectively. At the two highest doses, pulegone induced atonia, decreased blood creatinine content, lowered terminal body weight and caused histopathological changes in the liver and in the white matter of cerebellum. For menthol at all dose levels a significant increase in absolute and relative liver weights and vacuolisation of hepatocytes was found. No sign of encephalopathy was observed in rats given menthol.
AB - Pulegone and menthol, components of peppermint oil, were investigated in rats. The substances were administered by gavage for 28 days at 0, 20, 80, 160 mg pulegone and 0, 200, 400, 800 mg menthol/kg body wt./day, respectively. At the two highest doses, pulegone induced atonia, decreased blood creatinine content, lowered terminal body weight and caused histopathological changes in the liver and in the white matter of cerebellum. For menthol at all dose levels a significant increase in absolute and relative liver weights and vacuolisation of hepatocytes was found. No sign of encephalopathy was observed in rats given menthol.
U2 - 10.1016/0378-4274(83)90121-2
DO - 10.1016/0378-4274(83)90121-2
M3 - Journal article
SN - 0378-4274
VL - 19
SP - 211
EP - 215
JO - Toxicology Letters
JF - Toxicology Letters
IS - 3
ER -