Short-term study of the uptake of PrPSc by the Peyer’s patches in hamsters after oral exposure to scrapie

Ann-Louise Bergström, Tim Kåre Jensen, Peter M. H. Heegaard, Henriette Cordes Hvass, V. B. Hansen, H. Laursen, Peter Lind

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

The disease-associated prion protein (PrPSc) has been detected in the ileal Peyer's patches of lambs as early as one week after oral exposure to scrapie. In hamsters, the earliest reported time of PrPSc detection in the Peyer's patches after oral exposure to scrapie is 69 days post-infection. To evaluate the acute uptake of inoculum and to investigate whether the Peyer's patches constitute the primary site of entry for scrapie after oral exposure, hamsters were each exposed orally to 1 ml of a 10% brain homogenate from hamsters in the terminal stage of infection with the 263 K strain of the scrapie agent. PrPSc was demonstrated in the Peyer's patches only a few days after exposure, i.e., much earlier than previously reported. This study Supports the view that the Peyer's patches constitute at least one of the primary entry sites of PrPSc after oral exposure to scrapie.
Original languageEnglish
JournalJournal of Comparative Pathology
Volume134
Issue number2-3
Pages (from-to)126-133
ISSN0021-9975
DOIs
Publication statusPublished - 2006

Keywords

  • Peyer's patches
  • sheep
  • prion disease
  • hamster
  • scrapie

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