Short-term and long-term effects of transient exogenous cortisol manipulation on oxidative stress in juvenile brown trout

Kim Birnie-Gauvin, Kathryn S. Peiman, Martin Hage Larsen, Kim Aarestrup, William G Willmore, Steven J. Cooke

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Abstract

In the wild, animals are exposed to a growing number of stressors with increasing frequency and intensity, as a result of human activities and human-induced environmental change. To fully understand how wild organisms are affected by stressors, it is crucial to understand the physiology that underlies an organism's response to a stressor. Prolonged levels of elevated glucocorticoids are associated with a state of chronic stress and decreased fitness. Exogenous glucocorticoid manipulation reduces an individual's ability to forage, avoid predators and grow, thereby limiting the resources available for physiological functions like defence against oxidative stress. Using brown trout (Salmo trutta), we evaluated the short-term (2 weeks) and long-term (4 months over winter) effects of exogenous cortisol manipulations (versus relevant shams and controls) on the oxidative status of wild juveniles. Cortisol caused an increase in glutathione over a 2 week period and appeared to reduce glutathione over winter. Cortisol treatment did not affect oxidative stress levels or low molecular weight antioxidants. Cortisol caused a significant decrease in growth rates but did not affect predation risk. Over-winter survival in the stream was associated with low levels of oxidative stress and glutathione. Thus, oxidative stress may be a mechanism by which elevated cortisol causes negative physiological effects.
Original languageEnglish
JournalJournal of Experimental Biology
Volume220
Issue number9
Pages (from-to)1693-1700
ISSN0022-0949
DOIs
Publication statusPublished - 2017

Keywords

  • Antioxidants
  • Glucocorticoids
  • Glutathione
  • Oxidative ecology
  • Reactive oxygen species
  • Salmo trutta

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