TY - JOUR
T1 - Short and efficient diastereoselective synthesis of pyrrolidinone-containing dipeptide analogues
AU - Hosseini, Masood
AU - Grau, J.S.
AU - Sørensen, Kresten Kjær
AU - Søtofte, Inger
AU - Tanner, David Ackland
AU - Murray, A.
AU - Tønder, Janne Ejrnæs
PY - 2007
Y1 - 2007
N2 - The pyrrolidine-2,4-diones have been identified as a convenient starting point for the synthesis of peptide analogues. Herein we describe an optimized two-step reductive amination procedure, which provides a small library of pyrrolidinone-containing dipeptide analogues in high yield and excellent diastereoselectivity.
AB - The pyrrolidine-2,4-diones have been identified as a convenient starting point for the synthesis of peptide analogues. Herein we describe an optimized two-step reductive amination procedure, which provides a small library of pyrrolidinone-containing dipeptide analogues in high yield and excellent diastereoselectivity.
U2 - 10.1002/chin.200747187
DO - 10.1002/chin.200747187
M3 - Journal article
SN - 1477-0520
VL - 5
SP - 2207
EP - 2210
JO - Organic & Biomolecular Chemistry
JF - Organic & Biomolecular Chemistry
IS - 14
ER -