Short and efficient diastereoselective synthesis of pyrrolidinone-containing dipeptide analogues

Masood Hosseini, J.S. Grau, Kresten Kjær Sørensen, Inger Søtofte, David Ackland Tanner, A. Murray, Janne Ejrnæs Tønder

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

The pyrrolidine-2,4-diones have been identified as a convenient starting point for the synthesis of peptide analogues. Herein we describe an optimized two-step reductive amination procedure, which provides a small library of pyrrolidinone-containing dipeptide analogues in high yield and excellent diastereoselectivity.
Original languageEnglish
JournalOrganic & Biomolecular Chemistry
Volume5
Issue number14
Pages (from-to)2207-2210
ISSN1477-0520
DOIs
Publication statusPublished - 2007

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