Shear Stress and Its Effect on the Interaction of Myoblast Cells with Nanosized Drug Delivery Vehicles

Leticia Hosta Rigau, Brigitte Stadler

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

An important aspect to ensure progress in biomedicine is the fundamental understanding of the interaction of cells and tissue with (bio)materials. The consideration of shear stress in drug delivery and/or tissue engineering remains largely unexplored. To illustrate the fundamental relevance, we employ a microfluidic setup to evaluate the myoblast cell response to two prominent rug carrier systems, namely, liposomes and nanoparticles, in the presence of low shear stress. We show that positively charged carriers have an enhanced interaction with myoblast cells in the presence of shear stress. This effect can e translated into improved therapeutic response in terms of reduction in cell viability when delivering a cytotoxic compound or into a better translocation efficiency when using lipoplexes. Taken together, our fundamental findings open up now Possibilities in tissue engineering and drug delivery by considering an additional parameter when delivering beneficial compounds.
Original languageEnglish
JournalMolecular Pharmaceutics
Volume10
Issue number7
Pages (from-to)2707-2712
Number of pages6
ISSN1543-8384
DOIs
Publication statusPublished - 2013
Externally publishedYes

Keywords

  • Drug delivery
  • Shear stress
  • Liposomes
  • Cell viability
  • Translocation

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