Serum Tau Fragments Predict Return to Play in Concussed Professional Ice Hockey Players

Pashtun Shahim, Thomas Linemann, Dilek Inekci, Morten Asser Karsdal, Kaj Blennow, Yelverton Tegner, Henrik Zetterberg, Kim Henriksen

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

The diagnosis of sports-related concussion is mainly based on subjective clinical symptoms and neuropsychological tests. Therefore, reliable brain injury biomarkers to assess when it is safe to return to play are highly desirable. The overall objective of this study was to evaluate the utility of two newly described tau fragments for diagnosis and prognosis of sports-related concussions. This multi-center prospective cohort study involved all 12 teams of the top professional ice hockey league in Sweden. A total of 288 players consented to participate in the study. Thirty-five players sustained concussions, of whom 28 underwent repeated blood samplings at 1, 12, 36, and 144 h after the trauma, or when the player returned to play (7 to >90 days). There was no significant increase in the levels of Tau-A in post-concussion samples compared with preseason values. However, serum levels of Tau-C were significantly higher in post-concussion samples compared with preseason. Further, levels of Tau-A correlated with the duration of post-concussive symptoms. Tau-A in serum, which is newly discovered biomarker, could be used to predict when it is safe to return to play after a sports-related concussion.
Original languageEnglish
JournalJournal of Neurotrauma
Number of pages5
ISSN0897-7151
DOIs
Publication statusE-pub ahead of print - 2016
Externally publishedYes

Keywords

  • Ice hockey
  • Serum biomarkers
  • Sports-related concussion
  • Tau fragments

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