TY - JOUR
T1 - Serum selenium is low in newly diagnosed Graves´disease: a population-based study
AU - Bülow Pedersen, Inge
AU - Knudsen, Nils
AU - Carle, Allan
AU - Schomburg, Lutz
AU - Köhrle, Josef
AU - Jørgensen, Torben
AU - Rasmussen, Lone Banke
AU - Ovesen, Lars
AU - Laurberg, Peter
PY - 2013
Y1 - 2013
N2 - Selenium deficiency may play an important role in the initiation and progression of autoimmune thyroid disease. To compare serum selenium (s‐Se) values in patients with newly diagnosed autoimmune thyroid disease and controls from the Danish population. S‐Se was measured in triplicate by a fluorimetric method. Patients with newly diagnosed Graves’ disease (GD) (n = 97) or autoimmune overt hypothyroidism (AIH) (n = 96), euthyroid subjects with high serum levels of thyroid peroxidase antibody (TPO‐Ab) (TPO‐Ab > 1500 U/ml, n = 92) and random controls (n = 830). Differences in s‐Se values. S‐Se was lower in patients with GD than in controls (mean (SD), GD: 89·9 μg/l (18·4); controls: 98·8 μg/l (19·7), P < 0·01). This was confirmed in a multivariate logistic regression model adjusting for age, sex, mineral supplements, smoking, geographical region and time of sampling (P < 0·01). In a linear model, s‐Se was similar in patients with AIH (mean (SD): 98·4 μg/l (24·9)) and in controls (P = 0·86). In the multivariate model however, s‐Se was marginally lower in patients with AIH compared to controls (P = 0·04). There was no significant difference in s‐Se between euthyroid participants with high TPO‐Ab and random controls (linear: P = 0·97; multivariate: P = 0·27). Patients with newly diagnosed GD and AIH had significantly lower s‐Se compared with random controls. Our observation supports the postulated link between inadequate selenium supply and overt autoimmune thyroid disease, especially GD.
AB - Selenium deficiency may play an important role in the initiation and progression of autoimmune thyroid disease. To compare serum selenium (s‐Se) values in patients with newly diagnosed autoimmune thyroid disease and controls from the Danish population. S‐Se was measured in triplicate by a fluorimetric method. Patients with newly diagnosed Graves’ disease (GD) (n = 97) or autoimmune overt hypothyroidism (AIH) (n = 96), euthyroid subjects with high serum levels of thyroid peroxidase antibody (TPO‐Ab) (TPO‐Ab > 1500 U/ml, n = 92) and random controls (n = 830). Differences in s‐Se values. S‐Se was lower in patients with GD than in controls (mean (SD), GD: 89·9 μg/l (18·4); controls: 98·8 μg/l (19·7), P < 0·01). This was confirmed in a multivariate logistic regression model adjusting for age, sex, mineral supplements, smoking, geographical region and time of sampling (P < 0·01). In a linear model, s‐Se was similar in patients with AIH (mean (SD): 98·4 μg/l (24·9)) and in controls (P = 0·86). In the multivariate model however, s‐Se was marginally lower in patients with AIH compared to controls (P = 0·04). There was no significant difference in s‐Se between euthyroid participants with high TPO‐Ab and random controls (linear: P = 0·97; multivariate: P = 0·27). Patients with newly diagnosed GD and AIH had significantly lower s‐Se compared with random controls. Our observation supports the postulated link between inadequate selenium supply and overt autoimmune thyroid disease, especially GD.
U2 - 10.1111/cen.12185
DO - 10.1111/cen.12185
M3 - Journal article
C2 - 23448365
VL - 79
SP - 584
EP - 590
JO - Clinical Endocrinology
JF - Clinical Endocrinology
SN - 0300-0664
IS - 4
ER -