Serum levels of chicken mannan-binding lectin (MBL) during virus infections; indication that chicken MBL is an acute phase reactant

O.L. Nielsen, J. C. Jensenius, Poul Henrik Jørgensen, S.B. Laursen

    Research output: Contribution to journalJournal articleResearchpeer-review

    Abstract

    Mannan-binding lectin (MBL) is a serum collectin which is believed to be an opsonin of the innate immune defence against various microorganisms. MBL is a minor acute phase reactant in man. We investigated the concentration of serum MBL in chickens infected with infectious bronchitis virus (IBV) and infectious laryngotracheitis virus (ILTV). The concentration of serum MBL increased about twofold (from approximately 6 to 12 mu g/ml) due to these viral infections. The concentration peaked 3-7 days after infection with IBV, and 3-5 days after ILTV infection, depending on the ILTV strain used. The increased levels returned to normal values 6-10 days after infection. The results indicated that MBL is a minor acute phase reactant in chickens.
    Original languageEnglish
    JournalVeterinary Immunology and Immunopathology
    Volume70
    Issue number3-4
    Pages (from-to)309-316
    ISSN0165-2427
    DOIs
    Publication statusPublished - 1999

    Keywords

    • MBL
    • acute phase response
    • chickens
    • mannan-binding lectin
    • viral infections

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