Serum levels of chicken mannan-binding lectin (MBL) during virus infections; indication that chicken MBL is an acute phase reactant

O.L. Nielsen; J. C. Jensenius; Poul Henrik Jørgensen; S.B. Laursen

doi:10.1016/S0165-2427(99)00090-2

Serum levels of chicken mannan-binding lectin (MBL) during virus infections; indication that chicken MBL is an acute phase reactant

O.L. Nielsen, J. C. Jensenius, Poul Henrik Jørgensen, S.B. Laursen

Technical University of Denmark

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

Mannan-binding lectin (MBL) is a serum collectin which is believed to be an opsonin of the innate immune defence against various microorganisms. MBL is a minor acute phase reactant in man. We investigated the concentration of serum MBL in chickens infected with infectious bronchitis virus (IBV) and infectious laryngotracheitis virus (ILTV). The concentration of serum MBL increased about twofold (from approximately 6 to 12 mu g/ml) due to these viral infections. The concentration peaked 3-7 days after infection with IBV, and 3-5 days after ILTV infection, depending on the ILTV strain used. The increased levels returned to normal values 6-10 days after infection. The results indicated that MBL is a minor acute phase reactant in chickens.

Original language	English
Journal	Veterinary Immunology and Immunopathology
Volume	70
Issue number	3-4
Pages (from-to)	309-316
ISSN	0165-2427
DOIs	https://doi.org/10.1016/S0165-2427(99)00090-2
Publication status	Published - 1999

Keywords

MBL
acute phase response
chickens
mannan-binding lectin
viral infections

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title = "Serum levels of chicken mannan-binding lectin (MBL) during virus infections; indication that chicken MBL is an acute phase reactant",

abstract = "Mannan-binding lectin (MBL) is a serum collectin which is believed to be an opsonin of the innate immune defence against various microorganisms. MBL is a minor acute phase reactant in man. We investigated the concentration of serum MBL in chickens infected with infectious bronchitis virus (IBV) and infectious laryngotracheitis virus (ILTV). The concentration of serum MBL increased about twofold (from approximately 6 to 12 mu g/ml) due to these viral infections. The concentration peaked 3-7 days after infection with IBV, and 3-5 days after ILTV infection, depending on the ILTV strain used. The increased levels returned to normal values 6-10 days after infection. The results indicated that MBL is a minor acute phase reactant in chickens.",

keywords = "MBL, acute phase response, chickens, mannan-binding lectin, viral infections",

author = "O.L. Nielsen and Jensenius, {J. C.} and J{\o}rgensen, {Poul Henrik} and S.B. Laursen",

year = "1999",

doi = "10.1016/S0165-2427(99)00090-2",

language = "English",

volume = "70",

pages = "309--316",

journal = "Veterinary Immunology and Immunopathology",

issn = "0165-2427",

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}

Serum levels of chicken mannan-binding lectin (MBL) during virus infections; indication that chicken MBL is an acute phase reactant. / Nielsen, O.L.; Jensenius, J. C.; Jørgensen, Poul Henrik et al.
In: Veterinary Immunology and Immunopathology, Vol. 70, No. 3-4, 1999, p. 309-316.

Research output: Contribution to journal › Journal article › Research › peer-review

TY - JOUR

T1 - Serum levels of chicken mannan-binding lectin (MBL) during virus infections; indication that chicken MBL is an acute phase reactant

AU - Nielsen, O.L.

AU - Jensenius, J. C.

AU - Jørgensen, Poul Henrik

AU - Laursen, S.B.

PY - 1999

Y1 - 1999

N2 - Mannan-binding lectin (MBL) is a serum collectin which is believed to be an opsonin of the innate immune defence against various microorganisms. MBL is a minor acute phase reactant in man. We investigated the concentration of serum MBL in chickens infected with infectious bronchitis virus (IBV) and infectious laryngotracheitis virus (ILTV). The concentration of serum MBL increased about twofold (from approximately 6 to 12 mu g/ml) due to these viral infections. The concentration peaked 3-7 days after infection with IBV, and 3-5 days after ILTV infection, depending on the ILTV strain used. The increased levels returned to normal values 6-10 days after infection. The results indicated that MBL is a minor acute phase reactant in chickens.

AB - Mannan-binding lectin (MBL) is a serum collectin which is believed to be an opsonin of the innate immune defence against various microorganisms. MBL is a minor acute phase reactant in man. We investigated the concentration of serum MBL in chickens infected with infectious bronchitis virus (IBV) and infectious laryngotracheitis virus (ILTV). The concentration of serum MBL increased about twofold (from approximately 6 to 12 mu g/ml) due to these viral infections. The concentration peaked 3-7 days after infection with IBV, and 3-5 days after ILTV infection, depending on the ILTV strain used. The increased levels returned to normal values 6-10 days after infection. The results indicated that MBL is a minor acute phase reactant in chickens.

KW - MBL

KW - acute phase response

KW - chickens

KW - mannan-binding lectin

KW - viral infections

U2 - 10.1016/S0165-2427(99)00090-2

DO - 10.1016/S0165-2427(99)00090-2

M3 - Journal article

SN - 0165-2427

VL - 70

SP - 309

EP - 316

JO - Veterinary Immunology and Immunopathology

JF - Veterinary Immunology and Immunopathology

IS - 3-4

ER -

Serum levels of chicken mannan-binding lectin (MBL) during virus infections; indication that chicken MBL is an acute phase reactant

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Keywords

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