Serotype Specificity of Antibodies against Foot-and-Mouth Disease Virus in Cattle in Selected Districts in Uganda

F.N. Mwiine, C. Ayebazibwe, W. Olaho-Mukani, S. Alexandersen, S.N. Balinda, C. Masembe, A.R.A. Okurut, Laurids Siig Christensen, K.J. Sørensen, Kirsten Tjørnehøj

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Uganda had an unusually large number of foot-and-mouth disease (FMD) outbreaks in 2006, and all clinical reports were in cattle. A serological investigation was carried out to confirm circulating antibodies against foot-and-mouth disease virus (FMDV) by ELISA for antibodies against non-structural proteins and structural proteins. Three hundred and forty-nine cattle sera were collected from seven districts in Uganda, and 65% of these were found positive for antibodies against the non-structural proteins of FMDV. A subset of these samples were analysed for serotype specificity of the identified antibodies. High prevalences of antibodies against non-structural proteins and structural proteins of FMDV serotype O were demonstrated in herds with typical visible clinical signs of FMD, while prevalences were low in herds without clinical signs of FMD. Antibody titres were higher against serotype O than against serotypes SAT 1, SAT 2 and SAT 3 in the sera investigated for serotype-specific antibodies. Only FMDV serotype O virus was isolated from one probang sample. This study shows that the majority of the FMD outbreaks in 2006 in the region studied were caused by FMDV serotype O; however, there was also evidence of antibodies to both SAT 1 and SAT 3 in one outbreak in a herd inside Queen Elizabeth national park area.
Original languageEnglish
JournalTransboundary and Emerging Diseases
Volume57
Issue number5
Pages (from-to)365-374
ISSN1865-1674
DOIs
Publication statusPublished - 2010

Keywords

  • antibodies
  • Uganda
  • serotype-specific
  • cattle
  • foot-and-mouth disease

Cite this

Mwiine, F. N., Ayebazibwe, C., Olaho-Mukani, W., Alexandersen, S., Balinda, S. N., Masembe, C., Okurut, A. R. A., Christensen, L. S., Sørensen, K. J., & Tjørnehøj, K. (2010). Serotype Specificity of Antibodies against Foot-and-Mouth Disease Virus in Cattle in Selected Districts in Uganda. Transboundary and Emerging Diseases, 57(5), 365-374. https://doi.org/10.1111/j.1865-1682.2010.01157.x