Serological response to vaccination against avian influenza in zoo-birds using an inactivated H5N9 vaccine

Mads F. Bertelsen, Joan Klausen, Elisabeth Holm, Carsten Grondahl, Poul Henrik Jørgensen

    Research output: Contribution to journalJournal articleResearchpeer-review

    Abstract

    Five hundred and forty birds in three zoos were vaccinated twice against avian influenza with a 6-week interval using an inactivated H5N9 vaccine. Serological response was evaluated by hemagglutination inhibition test 4-6 weeks following the second vaccine administration. 84% of the birds seroconverted, and 76% developed a titre >= 32. The geometric mean titre after vaccination was 137. A significant species variation in response was noted; penguins, pelicans, ducks, geese, herons, Guinea fowl, cranes, cockatiels, lovebirds, and barbets showed very poor response to vaccination, while very high titres and seroconversion rates were seen in flamingos, ibis, rheas, Congo peafowl, black-winged stilts, amazon parrots, and kookaburras.
    Original languageEnglish
    JournalVaccine
    Volume25
    Issue number22
    Pages (from-to)4345-4349
    ISSN0264-410X
    DOIs
    Publication statusPublished - 2007

    Keywords

    • exotic birds
    • H5N9
    • vaccination
    • avian influenza

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